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Volume 17, Number 4—April 2011

Dispatch

Rapid Genotyping of Swine Influenza Viruses

Polly W.Y. Mak, Chloe K.S. Wong, Olive T.W. Li, Kwok Hung Chan, Chung Lam Cheung, Edward S. Ma, Richard J. Webby, Yi Guan, Joseph S. Malik Peiris, and Leo L.M. PoonComments to Author 
Author affiliations: Author affiliations: The University of Hong Kong, Hong Kong Special Administrative Region, People’s Republic of China (P.W.Y. Mak, C.K.S. Wong, O.T.W. Li, K.H. Chan, C.L. Cheung, E.S. Ma, Y. Guan, J.S.M. Peiris, L.L.M. Poon); St. Jude Children’s Research Hospital, Memphis, Tennessee, USA (R.J. Webby); Hong Kong University–Pasteur Research Centre, Hong Kong (J.S.M. Peiris)

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Table 2

Summary of expected genotyping results of swine and human influenza viruses*

Virus PB2 PB1 PA HA NP NA† M NS
Pandemic (H1N1) 2009 + + + + + + + + + + + + + + + +
Swine Eurasian avian-like – – – – – – – – – – – + – + – –
Swine triple reassortant – + – + – + – + – + – – – – – +
Human seasonal subtypes H1 and H3 – – – – – – – – – – – – – – – –

*PB, polymerase basic protein; PA, polymerase acidic protein; HA, hemagglutinin; NP, nucleocapsid protein; NA, neuraminidase; M, matrix protein; NS, nonstructural protein. Red symbols indicate pandemic (H1N1) 2009 virus–specific probe results; black symbols indicate SYBR Green results; gray shading indicates sister clade of pandemic (H1N1) 2009 virus for each virus segment.
†N2 and some of the N1 within swine Euarasian avian-like lineage are expected to be double negative in the NA test.

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