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Volume 18, Number 1—January 2012

Letter

Pulmonary Infection Caused by Mycobacterium conceptionense

Seon Young Kim, Myung Shin Kim, Ho Eun Chang, Jae-Joon Yim, Jae-Ho Lee, Sang Hoon Song, Kyoung Un ParkComments to Author , Junghan Song, and Eui-Chong Kim
Author affiliations: Seoul National University College of Medicine, Seoul, South Korea (S.Y. Kim, J.-J. Yim, J.-H. Lee, S.H. Song, K.U. Park, J. Song, E.-C. Kim); Seoul National University Bundang Hospital, Gyeonggi-do, South Korea (M.S. Kim, H.E, Chang, J.-H. Lee, S.H. Song, K.U. Park, J. Song)

Main Article

Table

Summary of cases of Mycobacterium conceptionense infection*

Patient no. Age, y/ sex Underlying illness Clinical presentation M. conceptionense source Sequencing results† Treatment Outcome Ref
1 69/F Chronic lung disease Chronic cough and recurrent fever; multifocal lung lesion and lymphadenopathy seen on chest CT image Sputum (2×) tuf, 16S rDNA (1,441 and 458 bp; 100% match) CLA, RIF, EMB Improved after 2 mo treatment This article
2 70/M Parkinson disease Asymptomatic; small nodule seen on chest CT image Sputum (1×) tuf CLA Asymptomatic This article
3 70/M Tongue cancer Respiratory failure, Streptococcus pneumoniae septicemia; lung lesion on chest CT image Sputum (2×) tuf, 16S rDNA (400 and 460 bp; 100% match) CLA, LVX, IPM, AMK, VAN Died This article
4 53/M Lung tuberculosis Asymptomatic after completion of antituberculosis treatment Sputum (1×) tuf, 16S rDNA (459 bp; 100% match) Observation Asymptomatic This article
5‡ 31/F Posttraumatic osteitis Wound liquid outflow 3 mo after treatment for open fracture Wound liquid, bone tissue biopsy, excised skin tissue 16S rDNA, soda, hsp65, recA, rpoB AMC Not reported (1)
6‡ 43/F Subcutaneous abscess without trauma Painful swelling and erythematous ankle; abscess detected by MRI Abscess aspirate 16S rDNA (1,464 bp) COT, CLA, DOX, LIN Improved after 5 mo treatment (2)
7‡ 58/F Breast implant infection Fever and wound discharge Wound discharge, surgical drainage rpoB CIP, AZY, DOX Unremarkable results at 2-mo follow-up after 18 mo treatment (3)
8 50/F Face surgery with fat grafting Erythematous nodules and purulent discharge Wound discharge 16S rDNA, rpoB AMK, LVX, CFX, CLA, SXT Recovered after 1 mo treatment (4)

*Ref, reference; CT, computed tomography; CLA, clarithromycin; RIF, rifampin; EMB, ethambutol; LVX, levofloxacin; IPM, imipenem; AMK, amikacin; VAN, vancomycin; AMC, amoxicillin/clavulanic acid; MRI, magnetic resonance imaging COT, cotrimoxazole; DOX, doxycycline; LIN, linezolid; CIP, ciprofloxacin; AZY, azithromycin; CFX, cefoxitin; SXT, sulfamethoxazole/trimethoprim.
†Sequences of the isolates were compared with the tuf gene and 16S rDNA gene sequence of the type strain CIP 108544T (GenBank accession nos. EU191943.1 and AY859684.1, respectively).
‡Data modified from Thibeaut et al. (3).

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