Volume 18, Number 1—January 2012
Letter
Pulmonary Infection Caused by Mycobacterium conceptionense
Seon Young Kim, Myung Shin Kim, Ho Eun Chang, Jae-Joon Yim, Jae-Ho Lee, Sang Hoon Song, Kyoung Un Park
, Junghan Song, and Eui-Chong Kim
, Junghan Song, and Eui-Chong KimTable
Summary of cases of Mycobacterium conceptionense infection*
| Patient no. | Age, y/ sex | Underlying illness | Clinical presentation | M. conceptionense source | Sequencing results† | Treatment | Outcome | Ref |
|---|---|---|---|---|---|---|---|---|
| 1 | 69/F | Chronic lung disease | Chronic cough and recurrent fever; multifocal lung lesion and lymphadenopathy seen on chest CT image | Sputum (2×) | tuf, 16S rDNA (1,441 and 458 bp; 100% match) | CLA, RIF, EMB | Improved after 2 mo treatment | This article |
| 2 | 70/M | Parkinson disease | Asymptomatic; small nodule seen on chest CT image | Sputum (1×) | tuf | CLA | Asymptomatic | This article |
| 3 | 70/M | Tongue cancer | Respiratory failure, Streptococcus pneumoniae septicemia; lung lesion on chest CT image | Sputum (2×) | tuf, 16S rDNA (400 and 460 bp; 100% match) | CLA, LVX, IPM, AMK, VAN | Died | This article |
| 4 | 53/M | Lung tuberculosis | Asymptomatic after completion of antituberculosis treatment | Sputum (1×) | tuf, 16S rDNA (459 bp; 100% match) | Observation | Asymptomatic | This article |
| 5‡ | 31/F | Posttraumatic osteitis | Wound liquid outflow 3 mo after treatment for open fracture | Wound liquid, bone tissue biopsy, excised skin tissue | 16S rDNA, soda, hsp65, recA, rpoB | AMC | Not reported | (1) |
| 6‡ | 43/F | Subcutaneous abscess without trauma | Painful swelling and erythematous ankle; abscess detected by MRI | Abscess aspirate | 16S rDNA (1,464 bp) | COT, CLA, DOX, LIN | Improved after 5 mo treatment | (2) |
| 7‡ | 58/F | Breast implant infection | Fever and wound discharge | Wound discharge, surgical drainage | rpoB | CIP, AZY, DOX | Unremarkable results at 2-mo follow-up after 18 mo treatment | (3) |
| 8 | 50/F | Face surgery with fat grafting | Erythematous nodules and purulent discharge | Wound discharge | 16S rDNA, rpoB | AMK, LVX, CFX, CLA, SXT | Recovered after 1 mo treatment | (4) |
*Ref, reference; CT, computed tomography; CLA, clarithromycin; RIF, rifampin; EMB, ethambutol; LVX, levofloxacin; IPM, imipenem; AMK, amikacin; VAN, vancomycin; AMC, amoxicillin/clavulanic acid; MRI, magnetic resonance imaging COT, cotrimoxazole; DOX, doxycycline; LIN, linezolid; CIP, ciprofloxacin; AZY, azithromycin; CFX, cefoxitin; SXT, sulfamethoxazole/trimethoprim.
†Sequences of the isolates were compared with the tuf gene and 16S rDNA gene sequence of the type strain CIP 108544T (GenBank accession nos. EU191943.1 and AY859684.1, respectively).
‡Data modified from Thibeaut et al. (3).
