Fatal Respiratory Infections Associated with Rhinovirus Outbreak, Vietnam
Le Thanh Hai, Vu Thi Ngoc Bich, Le Kien Ngai, Nguyen Thi Ngoc Diep, Phan Huu Phuc, Viet Pham Hung, Walter R. Taylor, Peter Horby, Nguyen Thanh Liem, and Heiman F.L. Wertheim
Author affiliations: National Hospital of Pediatrics, Hanoi, Vietnam (L.T. Hai, L.K. Ngai, P.H. Phuc, V.P. Hung, N.T. Liem); Wellcome Trust Major Overseas Program Vietnam, Hanoi (V.T.N. Bich, N.T.N. Diep, W.R. Taylor, P. Horby, H.F.L. Wertheim); Oxford University Clinical Research Unit, Hanoi (W.R. Taylor, P. Horby, H.F.L. Wertheim); and University of Oxford, Oxford, UK (W.R. Taylor, P. Horby, H.F.L. Wertheim)
Figure. . . . Genotyping of human rhinovirus (HRV) from outbreak and control specimens by P1–P2 sequence analysis. We compared 19 HRVs from the outbreak orphanage (red), 5 HRVs from control orphanage blue), and the following P1-P2 sequences in GenBank, according to Lee et al. (3). HRV-A group (green): EU126769, EU126779, EU126767, EU126699, EU126682, EU126663, EU126716, EU126691, EU126709, EU126762; HRVB group (orange): EU126732, EU126689, EU126666, EU126753, EU126705, EU126746, HRV-C group (brown): EU126786, EU126772, EU126775, EU126777, EU126783, EU126788, EU126784, EU126781, EU126764. Two HRV sequences from hospitalized patients were included (HRV number in red box). Multiple sequence alignment was performed by using the BioEdit program package (Ibis Biosciences, Carlsbad, CA, USA). Nucleotide distances were analyzed with DNAdist, the neighbor-joining tree of BioEdit package. The consensus tree was visualized by TREEVIEW v1.6.6 (Institute of Biomedical and Life Sciences, University of Glasgow, Glasgow, UK). Scale bar indicates nucleotide substitutions per site.
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