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Volume 18, Number 11—November 2012

Dispatch

Seroprevalence of Influenza A(H1N1)pdm09 Virus Antibody, England, 2010 and 2011

Katja HoschlerComments to Author , Catherine Thompson, Nick Andrews, Monica Galiano, Richard Pebody, Joanna Ellis, Elaine Stanford, Marc Baguelin, Elizabeth Miller, and Maria Zambon
Author affiliations: Health Protection Agency, London, UK (K. Hoschler, C. Thompson, N. Andrews, M. Galiano, R. Pebody; J. Ellis, M. Baguelin, E Miller, M. Zambon); and Health Protection Agency, Manchester, UK (E. Stanford)

Main Article

Table 1

Seroprevalence of influenza A(H1N1)pdm09 virus antibody, England, 2010 and 2011*

Characteristic No. seropositive samples/no. total samples† (% seropositive samples, 95% CI)
Post–second wave‡
Pre–third
Post–third wave
HI MN HI MN HI MN
Age group, y

<5

36/98 (0.37, 0.27–0.47) 31/77 (0.4, 0.29–0.52) 94/182 (0.52, 0.44–0.59) 88/174 (0.51, 0.43–0.58) 99/160 (0.62, 0.54–0.69) 93/150 (0.62, 0.54–0.7)

5–14

132/213 (0.62, 0.55–0.69) 69/107 (0.64, 0.55–0.73) 142/244 (0.58, 0.52–0.64) 152/237 (0.64, 0.58–0.7) 155/200 (0.78, 0.71–0.83) 146/199 (0.73, 0.67–0.79)

15–24

68/154 (0.44, 0.36–0.52) 44/101 (0.44, 0.34–0.54) 152/405 (0.38, 0.33–0.42) 156/400 (0.39, 0.34–0.44) 216/320 (0.68, 0.62–0.73) 188/311 (0.6, 0.55–0.66)

25–44

66/200
(0.33, 0.27–0.4) 31/83 (0.37, 0.27–0.49) 106/370 (0.29, 0.24–0.34) 114/370 (0.31, 0.26–0.36) 187/294 (0.64, 0.58–0.69) 155/283 (0.55, 0.49–0.61)

45–64

59/220 0.27, 0.21–0.33) 42/110 (0.38, 0.29–0.48) 69/320 (0.22, 0.17–0.26) 93/318 (0.29, 0.24–0.35) 62/138 (0.45, 0.36–0.54) 52/135 (0.39, 0.3–0.47)

65–74

36/145
(0.25, 0.18–0.33) 27/87 (0.31, 0.22–0.42) 35/168 (0.21, 0.15–0.28) 42/167 (0.25, 0.19–0.32) 38/74 (0.51, 0.39–0.63) 38/74 (0.51, 0.39–0.63)

>75

55/172 (0.32, 0.25–0.4) 77/163 (0.47, 0.39–0.55) 16/93 (0.17, 0.1–0.26) 25/92 (0.27, 0.18–0.37) 46/71 (0.65, 0.53–0.76) 39/71 (0.55, 0.43–0.67)
Region§

Total

1,202 1,782 1,257

North West

561 624 337

South West

404 232 265

North East

237 526 179

East

0 292 122

Yorkshire and 
Humber

0 108 354

*HI, hemagglutination inhibition assay; MN, microneutralization assay.
†Samples with titers >32 by HI or >40 by MN,
‡For data consistency, samples from only North West, South West, and North East regions were included in this analysis because these regions also were among the 5 regions in pre– and post–third wave samples.
§Numbers by region describe total available number of samples (all analyzed at least by HI assay).

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