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Volume 18, Number 11—November 2012

Dispatch

Seroprevalence of Influenza A(H1N1)pdm09 Virus Antibody, England, 2010 and 2011

Katja HoschlerComments to Author , Catherine Thompson, Nick Andrews, Monica Galiano, Richard Pebody, Joanna Ellis, Elaine Stanford, Marc Baguelin, Elizabeth Miller, and Maria Zambon
Author affiliations: Health Protection Agency, London, UK (K. Hoschler, C. Thompson, N. Andrews, M. Galiano, R. Pebody; J. Ellis, M. Baguelin, E Miller, M. Zambon); and Health Protection Agency, Manchester, UK (E. Stanford)

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Table 2

Seroincidence estimates of influenza A(H1N1)pdm09 virus antibody, England, 2010 and 2011

Age group, y Change in antibody level, % (95% CI)
Post–second wave to pre–third wave*
Pre–third wave to post–third wave†
Hemagglutination inhibition Microneutralization Hemagglutination inhibition Microneutralization
<5 15 (3–27) 10 (–3 to 24) 10 (0–21) 11 (1–22)
5–14 –4 (–13 to 5) 0 (–11 to 11) 19 (11–28) 9 (1–18)
15–24 –7 (–16 to 3) –5 (–15 to 6) 30 (23–37) 21 (14–29)
25–44 –4 (–12 to 4) –7 (–18 to 5) 35 (28–42) 24 (16–31)
45–64 –5 (–13 to 2) –9 (–19 to 1) 23 (15–33) 9 (0–19)
65–74 –4 (–13 to 5) –6 (–18 to 6) 31 (18–43) 26 (13–39)
>75 –15 (–25 to –4) –20 (–32 to –8) 48 (34–61) 28 (13–42)

*Antibody levels at the end of the 2009–10 winter season compared with those before the 2010–11 season.
†Antibody levels before and after the 2010–11 season.

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