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Volume 18, Number 12—December 2012

Dispatch

Arctic-like Rabies Virus, Bangladesh

Khondoker Mahbuba Jamil, Kamruddin AhmedComments to Author , Moazzem Hossain, Takashi Matsumoto, Mohammad Azmat Ali, Sohrab Hossain, Shakhawat Hossain, Aminul Islam, Mohammad Nasiruddin, and Akira Nishizono
Author affiliations: Author affiliations: Institute of Epidemiology, Disease Control, and Research, Dhaka, Bangladesh (K.M. Jamil); Oita University, Oita, Japan (K. Ahmed, T. Matsumoto, A. Nishizono); Ministry of Health and Family Welfare, Dhaka (M. Hossain); Dhaka City Corporation, Dhaka (M.A. Ali, S. Hossain, A. Islam, M. Nasiruddin); Tongi Municipality, Tongi, Bangladesh (S. Hossain)

Main Article

Table 2

Substitutions in genome sequence of rabies virus BDR5 from Bangladesh compared with genome sequence of strain from India (AY956319)*

Protein, amino acid substitution Site/domain/region of protein†
N

Asp378 → Glu378

Antigenic site IV

Gln422 → Arg422



P

Ser64 → Pro64

Variable domain I

Gln71 → Thr71

Variable domain I

Asn90 → Ser90

N protein binding site in variable domain II

Pro159 → Ser159

N protein binding site in variable domain II

His162 → Ser162

N protein binding site in variable domain II

Asn166 → Ser166

N protein binding site in variable domain II

Ala174 → Val174


N protein binding site in variable domain II
M

Leu21 → Pro21

Ser46 → Gly46

Ile168 →Val168



G

Ala-(minus)15 → Val-15

Signal peptide

Val-(minus)6 → Phe-6

Signal peptide

Val7 → Ile7

Asp146 → Asn146

Putative additional N-glycosylation: NKS

Val427 → Ile427

Arg462 → Gly462

Transmembrane domain

His465 → Arg465

Transmembrane domain

Gly473 → Ser473


Transmembrane domain
L

Asp18 → Glu18

Ala19 → Thr19

Arg315 → Lys315

Conserved domain I

Val361 → Leu361

Conserved domain I

His640 → Gln640

Conserved domain III

Lys657 → Arg657

Conserved domain III

Ala966 → Thr966

Conserved domain IV

Pro1133 → Ser1133

Conserved domain V

Arg1307 Lys1307

Conserved domain IV

Asp1373 → Gly1373

Leu1626 → Val1626

Leu1654 → Ser1654

Val1755 → Ile1755

Cys1825 → Tyr1825

Asn1841 → Lys1841

Gln1845 → His1845

Cys1872 → Phe1872

Asn2091 → Ser2091

*N, nucleoprotein; P, phosphoprotein; M, matrix protein; G, glycoprotein; L, polymerase.
†– indicates that the amino acid substitution was in a location that has no site/domain/region name. NKS, asparagine-lysine-serine.

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