Emerging Infectious Disease ISSN: 1080-6059

Nonprimate Hepaciviruses in Domestic Horses, United Kingdom

Sinéad Lyons, Amit Kapoor, Colin Sharp, Bradley S. Schneider, Nathan D. Wolfe, Geoff Culshaw, Brendan Corcoran, Bruce C. McGorum, and Peter Simmonds

Author affiliations: Author affiliations: University of Edinburgh, Edinburgh, Scotland, UK (S. Lyons, C. Sharp, G. Culshaw, B. Corcoran, B.C. McGorum, P. Simmonds); Columbia University, New York, New York, USA (A. Kapoor); Global Viral Forecasting Initiative, San Francisco, California, USA (B.S. Schneider, N.D. Wolfe)

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Figure

Phylogenetic analysis of A) 5′ untranslated region, B) nonstructural protein 3, and C) nonstructural protein 5B regions of nonprimate hepatitis virus sequence amplified from screen-positive study animals. Neighbor-joining trees of nucleotide sequences from each genome region were constructed from Jukes-Cantor corrected pairwise distances calculated by using the program MEGA version 5 (25; datasets were bootstrap re-sampled 500× to indicate robustness of branching (values >70% shown on branche

Figure. . . Phylogenetic analysis of A) 5′ untranslated region, B) nonstructural protein 3, and C) nonstructural protein 5B regions of nonprimate hepatitis virus sequence amplified from screen-positive study animals. Neighbor-joining trees of nucleotide sequences from each genome region were constructed from Jukes-Cantor corrected pairwise distances calculated by using the program MEGA version 5 (25; datasets were bootstrap re-sampled 500× to indicate robustness of branching [values >70% shown on branches]). The hepacivirus genotype 1a sequence, M62321, was used to root the tree (not shown). Scale bars indicate nucleotide substitutions per site.

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