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Volume 18, Number 2—February 2012


Pandemic (H1N1) 2009 in Captive Cheetah

Beate CrossleyComments to Author , Sharon Hietala, Tania Hunt, Glenn Benjamin, Marie Martinez, Daniel Darnell, Adam Rubrum, and Richard Webby
Author affiliations: California Animal Health and Food Safety Laboratory, University of California, Davis, California, USA (B. Crossley, S. Hietala); Safari West, Santa Rosa, California, USA (T. Hunt, G. Benjamin, M. Martinez); St. Jude Children’s Research Hospital, Memphis, Tennessee, USA (D. Darnell, A. Rubrum, R. Webby)

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Clinical and virologic course of infection in 3 groups of ferrets experimentally infected with different strains of pandemic (H1N1) 2009 virus, by strain*

Virus Average maximum % weight loss (range) Average maximum increase in temperature, °C Observed clinical signs
A/Cheetah/CA/D0912239/2010 6.2 (2.3–10.3) 0.9 (0.9–2.7) Sneezing (2 animals), nasal discharge (1 animal)
A/Ukraine/N6/2009 4.6 (2.8–7.1) 1.2 (0.9, 1.5) None
A/TN/892/2009 7.0 (3.5–11.0) 1.4 (1.2–1.8) None

*Five ferrets in each group were intranasally inoculated with a 105.5 50% tissue culture infectious dose of virus.

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