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Volume 18, Number 2—February 2012

Letter

Human and Porcine Hepatitis E Viruses, Southeastern Bolivia

Michael A. PurdyComments to Author , Maria Chiara Dell’Amico, José Luis Gonzales, Higinio Segundo, Francesco Tolari, Maurizio Mazzei, Alessandro Bartoloni, and Yury E. Khudyakov
Author affiliations: Centers for Disease Control and Prevention, Atlanta, Georgia USA (M. A. Purdy, Y. E. Khudyakov); Università di Pisa, Pisa, Italy (M. C. Dell’Amico, F. Tolari, M. Mazzei); Laboratorio de Investigación y Diagnóstico Veterinario, Santa Cruz, Bolivia (J. L. Gonzales); Distrito de Salud Cordillera, Santa Cruz, Bolivia (H. Segundo); Università degli Studi di Firenze, Firenze, Italy (A. Bartoloni)

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Table

Model estimates of time to most common recent ancestor for HEV ORF2 nucleotide sequences, southeastern Bolivia*

Model Start position Stop position Bolivia sequence GenBank sequence Mean tMRCA, y 95% HPD, y
Mean ± SD rate of substitutions/site/y
Lower Upper
A 826 1173 X NU 55.31 16.26 108.05 3.27 × 10–3 ± 9.44 × 10–6
B 826 1173 NU 3i and 3e 148.63 3.01 291.46 1.88 × 10–2 ± 6.41 × 10–4
C 826 1173 X X 144.45 38.66 298.20 3.43 × 10–3 ± 4.74 × 10–5
D 826 1173 NU X 328.05 45.59 681.90 2.12 × 10–3 ± 7.33 × 10–5
E 1 1980 NU X 296.06 163.40 467.97 9.27 × 10–4 ± 1.25 × 10–5
F 826 1173 3 seqs X 275.45 40.06 635.32 2.40 × 10–3 ± 5.06 × 10–5

*HEV, hepatitis E virus; ORF, open reading frame; tMRCA, time to the most recent common ancestor; HPD, highest posterior density boundary; X, sequences was used; NU, not used; 3i and 3e, subtype 3i and 3e sequences were used; 3 seqs, sequences (CV2, CB9, and HB2BA053) from Bolivia were used.

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