Volume 18, Number 2—February 2012
Multiorgan Dysfunction Caused by Travel-associated African Trypanosomiasis
|Disease stage||Drug, route of administration||Regimen||Adverse effects|
|First||Suramin, intravenous||Test dose of 100 mg in 100 mL 0.9% saline over 30 min on day 0; and 5 doses of 20 mg/kg (maximum 1 g/dose) in 250 mL 0.9% saline over 3 h on days 1, 3, 7, 14, 21||Hypersensitivity reactions (early and late); nephrotoxicity, hepatotoxicity, hemolytic anemia, peripheral neuropathy, agranulocytosis, thrombocytopenia, and cutaneous reactions|
|Second||Melarsoprol, intravenous||2.0–3.6 mg/kg/d (maximum 180 mg/d) for 3 d; after 7 d, 3.6 mg/kg/d for 3 d; after 7 more d, 3.6 mg/kg/d for 3 d†||Encephalopathy, cutaneous reactions, peripheral neuropathy, cardiac arrhythmias, thrombophlebitis, fever, and gastric upset|
*Source of drug regimen: Brun et al. (2) and Abramowicz (3).
†In frail patients, begin with 18 mg melarsoprol and progressively increase dose (3). Pretreatment with suramin for 2–4 d is recommended for debilitated patients.
1Current affiliation: Worthing Hospital, Worthing, UK.
- Page created: January 24, 2012
- Page last updated: January 24, 2012
- Page last reviewed: January 24, 2012
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