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Volume 18, Number 5—May 2012

Dispatch

Human Infections with Novel Reassortant Influenza A(H3N2)v Viruses, United States, 2011

Stephen Lindstrom, Rebecca Garten, Amanda Balish, Bo Shu, Shannon Emery, LaShondra Berman, Nathelia Barnes, Katrina Sleeman, Larisa Gubareva, Julie Villanueva, and Alexander KlimovComments to Author 
Author affiliations: Centers for Disease Control and Prevention, Atlanta, Georgia, USA (S. Lindstrom, R. Garten, A. Balish, B. Shu, S. Emery, L. Berman, K. Sleeman, L. Gubareva, J. Villanueva, A. Klimov); Battelle, Atlanta (N. Barnes)

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Table 2

Hemagglutinin-inhibition assay results, including the 6 available influenza A(H3N2)v viruses isolated in 2011, United States*

Influenza virus strain (culture method) Titers to reference ferret antiserum
Specimen collection date
PER/16 KS/13 WI/12 PA/14 MN/11 X203 IN/08 IN/10
A/Perth/16/2009 (egg)† 1,280 <10 <10 <10 20 20 <10 <10 2009 Apr 7
A/Kansas/13/2009 (MDCK cells) <10 640 80 160 40 40 40 80 2009 Jul 29
A/Wisconsin/12/2010 (MDCK cells) <10 40 1,280 320 640 320 640 1,280 2010 Sep 10
A/Pennsylvania/14/2010 (egg) <10 160 320 640 320 320 640 640 2010 Oct 26
A/Minnesota/11/2010 (egg) <10 <10 320 160 640 1,280 320 160 2010 Nov 26
A/Minnesota/11/2010 X-203 (egg)‡ 10 <10 80 40 320 640 160 80 Not applicable
A/Indiana/08/2011 (MDCK cells)* <10 10 1,280 640 640 320 1,280 1,280 2011 Jul 24
A/Indiana/10/2011 (MDCK cells)* <10 40 1,280 320 1,280 640 1,280 1,280 2011 Oct 22
A/Indiana/10/2011 (egg)* <10 10 1,280 320 640 320 1,280 1,280 2011 Oct 22
A/Iowa/07/2011 (MDCK cells)* <10 10 1,280 640 1,280 640 1,280 2,560 2011 Nov 14
A/Iowa/08/2011 (MDCK cells)* <10 40 1,280 640 640 640 1,280 2,560 2011 Nov 14
A/Iowa/09/2011 (MDCK cells)* <10 40 1,280 640 1,280 640 2560 2,560 2011 Nov 14

*Influenza A(H3N2)v, virus variant identified in humans, United States, 2011. Gray shading indicates antigenically similar viruses.
†Current seasonal influenza A(H3N2) vaccine virus.
‡Reassortant virus possessing the hemagglutinin and neuraminidase genes of A/Minnesota/11/2010 and the remaining 6 genes of A/PR/8/34.

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