Volume 18, Number 6—June 2012
CME ACTIVITY
Pretransplant Fecal Carriage of Extended-Spectrum β-Lactamase–producing Enterobacteriaceae and Infection after Liver Transplant, France
Frédéric Bert
, Béatrice Larroque, Catherine Paugam-Burtz, Federica Dondero, François Durand, Estelle Marcon, Jacques Belghiti, Richard Moreau, and Marie-Hélène Nicolas-Chanoine
, Béatrice Larroque, Catherine Paugam-Burtz, Federica Dondero, François Durand, Estelle Marcon, Jacques Belghiti, Richard Moreau, and Marie-Hélène Nicolas-ChanoineTable 4
Comparison of patients with and without ESBLE infection, by univariate analysis, France, January 2001–April 2010*
| Variable | Patients with ESBLE infection, n = 39 | Patients without ESBLE infection, n = 671 | p value | |
|---|---|---|---|---|
| Preoperative data | ||||
| Mean age, y | 49 | 50 | 0.55 | |
| Male sex | 24 (61.5) | 466 (69.4) | 0.30 | |
| ESBLE fecal carriage | 13 (33.3) | 16 (2.4) | <0.0001 | |
| Viral hepatitis | 13 (33.3) | 248 (37.1) | 0.64 | |
| Hepatocellular carcinoma | 7 (17.9) | 214 (32.3) | 0.061 | |
| Alcoholism | 16 (41) | 219 (32.6) | 0.28 | |
| Acute liver failure | 11 (28.2) | 63 (9.4) | 0.0011 | |
| HIV infection | 1 (2.5) | 20 (3) | 1 | |
| MELD score >25 | 20 (51.3) | 143 (21.4) | <0.0001 | |
| Intensive care stay >48 h† | 14 (35.9) | 80 (11.2) | <0.0001 | |
| Hospital stay >10 d† | 20 (51.3) | 185 (27.6) | 0.0015 | |
| Spontaneous bacterial peritonitis† | 7 (17.9) | 63 (9.4) | 0.082 | |
| Bacteremia† | 5 (12.8) | 70 (10.4) | 0.59 | |
| Intraoperative data | ||||
| Mean duration of surgery, min | 488 | 509 | 0.12 | |
| Mean cold ischemia time, min | 472 | 484 | 0.47 | |
| Kidney transplant | 2 (5.1) | 39 (5.8) | 1 | |
| Living donor | 3 (7.9) | 56 (8.4) | 1 | |
| Mean no. units red blood cells transfused | 5.9 | 4.5 | 0.11 | |
| Roux-en-Y anastomosis | 4 (10.2) | 46 (7.6) | 0.53 | |
| Postoperative data | ||||
| Retransplantation | 3 (7.7) | 40 (6) | 0.72 | |
| Return to surgery | 23 (59) | 228 (34) | 0.0015 | |
| Acute renal failure | 24 (66.7) | 238 (38.1) | 0.0007 | |
*Values are no. (%) except as indicated. ESBLE, extended-spectrum β-lactamase–producing Enterobacteriaceae; MELD, Model for End-stage Liver Disease.
†In the 6 mo before liver transplant.
