Skip directly to search Skip directly to A to Z list Skip directly to site content
CDC Home

Volume 18, Number 7—July 2012

Research

Adenoviruses in Fecal Samples from Asymptomatic Rhesus Macaques, United States

Soumitra Roy1, Arbansjit Sandhu, Angelica Medina, David S. Clawson, and James M. WilsonComments to Author 
Author affiliations: University of Pennsylvania, Philadelphia, Pennsylvania, USA

Main Article

Table 1

Characterization of adenovirus isolates from rhesus fecal samples obtained from primate facilities in the United States*

Isolate Source† Particle titer Total yield Sequence analysis
A1123 ONPRC 4.0 × 1011 9.6 × 1011 Hexon similar to SAdV-3
A1128 Covance 6.0 × 1011 1.3 × 1012 Hexon similar to SAdV-3
A1129 Covance 6.1 × 1011 3.8 × 1013 Hexon (A1128)
A1139 Covance 4.7 × 1012 1.8 × 1012 Full genome
A1161 Covance 2.0 × 1012 4.3 × 1013 Hexon similar to SAdV-48
A1163 Covance 5.4 × 1012 5.4 × 1012 Full genome
A1166 Covance 2.8 × 1012 1.3 × 1011 Hexon (A1161)
A1169 Covance 1.1 × 1011 2.5 × 1013 Hexon (A1161)
A1173 Covance 5.2 × 1012 2.3 × 1012 Full genome
A1179 Covance 4.6 × 1012 1.0 × 1013 Hexon (A1128)
A1258 GTP 1.8 × 1012 2.6 × 1012 Full genome
A1261 GTP 8.7 × 1011 9.0 × 1012 Hexon (A1285)
A1285 GTP 2.7 × 1012 2.0 × 1013 Full genome
A1296 Covance 5.4 × 1012 7.3 × 1011 Full genome
A1297 Covance 3.7 × 1011 7.0 × 1011 Hexon (A1163)
A1312 Covance 6.1 × 1011 8.4 × 1011 Full genome
A1313 TNPRC 6.5 × 1011 1.4 × 1013 Hexon similar to A1312
A1327 TNPRC 2.4 × 1012 1.0 × 1012 Full genome
A1328 NEPRC 6.7 × 1011 2.7 × 1012 Hexon similar to SAdV-49
A1329 TNPRC 3.7 × 1012 9.2 × 1012 Hexon (A1312)
A1335 NEPRC 6.0 × 1012 2.8 × 1013 Full genome
A1339 TNPRC 3.1 × 1012 5.7 × 1012 Hexon (A1163)
A1340 Covance 5.1 × 1012 3.1 × 1013 Hexon (A1335)

*The total yield and the particle titer obtained from a 50-plate (150-mm) preparation are shown. In each case, the hexon region was PCR amplified and sequenced. Boldface indicates the 9 isolates that were completely sequenced. For the other isolates, the hexon sequences that are identical or very closely related (<5% nucleotide sequence dissimilarity) are indicated in parentheses. SAdV, simian adenovirus.
† ONPRC, Oregon National Primate Research Center (Beaverton, OR, USA); Covance, Covance, (Vienna, VA, USA); GTP, primate facility of the Gene Therapy Program at the University of Pennsylvania (Philadelphia, PA, USA); TNPRC, Tulane National Primate Research Center (Covington, LA, USA); NEPRC, New England Primate Research Center (Southborough, MA, USA).

Main Article

1Current affiliation: Crucell Holland, Leiden, the Netherlands.

Top of Page

USA.gov: The U.S. Government's Official Web PortalDepartment of Health and Human Services
Centers for Disease Control and Prevention   1600 Clifton Rd. Atlanta, GA 30333, USA
800-CDC-INFO (800-232-4636) TTY: (888) 232-6348 - Contact CDC–INFO