Volume 18, Number 8—August 2012
CME ACTIVITY
Vaccination of Health Care Workers to Protect Patients at Increased Risk for Acute Respiratory Disease
Gayle P. Dolan
, Rebecca C. Harris, Mandy Clarkson, Rachel Sokal, Gemma Morgan, Mitsuru Mukaigawara, Hiroshi Horiuchi, Rachel Hale, Laura Stormont, Laura Béchard-Evans, Yi-Sheng Chao, Sergey Eremin, Sara Martins, John S. Tam, Javier Peñalver, Arina Zanuzdana, and Jonathan S. Nguyen-Van-Tam
, Rebecca C. Harris, Mandy Clarkson, Rachel Sokal, Gemma Morgan, Mitsuru Mukaigawara, Hiroshi Horiuchi, Rachel Hale, Laura Stormont, Laura Béchard-Evans, Yi-Sheng Chao, Sergey Eremin, Sara Martins, John S. Tam, Javier Peñalver, Arina Zanuzdana, and Jonathan S. Nguyen-Van-TamTable 3
Cases of and consultations for acute respiratory disease in a review of the vaccination of health care workers to protect patients at risk for acute respiratory disease*
| Outcome measure (study) | Study design | Method of assessment | Measure of effect in patient population | Effect estimate (95% CI) |
|---|---|---|---|---|
| Clinically defined episodes of viral illness (Potter et al. [25]) |
Cluster RCT |
Not defined. No. episodes recorded by study nurses. |
OR, nonvaccinated and vaccinated patients | 0.64 (0.48–0.87) |
| OR, vaccinated patients | 0.40 (0.26–0.62) | |||
| OR, nonvaccinated patients |
0.98 (0.65–1.48) |
|||
| Lower respiratory tract infection | ||||
| Potter et al. (25) | Cluster RCT | Defined as 1) pulmonary crackles, wheeze, or tachypnea plus temperature >37.0°C or leukocyte count >10 × 109/L or 2) a positive sputum culture. No. episodes recorded by study nurses. | OR, nonvaccinated and vaccinated patients | 0.69 (0.40–1.19) |
| OR, vaccinated patients | 0.59 (0.25–1.38) | |||
| OR, nonvaccinated patients | 0.77 (0.38–1.57) | |||
| Thomas et al. (19) | Pooled data | OR, adjusted for clustering | 0.71 (0.29–1.71)† | |
*RCT, randomized controlled trial; OR, odds ratio. Boldface indicates statistical significance.
†p = 0.44. p value not reported for other categories.
