Volume 18, Number 8—August 2012
Vaccination of Health Care Workers to Protect Patients at Increased Risk for Acute Respiratory Disease
|Outcome measure (study)||Study design||Method of assessment||Measure of effect in patient population||Effect estimate (95% CI)|
|Clinically defined episodes of viral illness (Potter et al. )
||Not defined. No. episodes recorded by study nurses.
||OR, nonvaccinated and vaccinated patients||0.64 (0.48–0.87)|
|OR, vaccinated patients||0.40 (0.26–0.62)|
|OR, nonvaccinated patients
|Lower respiratory tract infection|
|Potter et al. (25)||Cluster RCT||Defined as 1) pulmonary crackles, wheeze, or tachypnea plus temperature >37.0°C or leukocyte count >10 × 109/L or 2) a positive sputum culture. No. episodes recorded by study nurses.||OR, nonvaccinated and vaccinated patients||0.69 (0.40–1.19)|
|OR, vaccinated patients||0.59 (0.25–1.38)|
|OR, nonvaccinated patients||0.77 (0.38–1.57)|
|Thomas et al. (19)||Pooled data||OR, adjusted for clustering||0.71 (0.29–1.71)†|
*RCT, randomized controlled trial; OR, odds ratio. Boldface indicates statistical significance.
†p = 0.44. p value not reported for other categories.