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Volume 18, Number 8—August 2012

CME ACTIVITY

Vaccination of Health Care Workers to Protect Patients at Increased Risk for Acute Respiratory Disease

Gayle P. DolanComments to Author , Rebecca C. Harris, Mandy Clarkson, Rachel Sokal, Gemma Morgan, Mitsuru Mukaigawara, Hiroshi Horiuchi, Rachel Hale, Laura Stormont, Laura Béchard-Evans, Yi-Sheng Chao, Sergey Eremin, Sara Martins, John S. Tam, Javier Peñalver, Arina Zanuzdana, and Jonathan S. Nguyen-Van-Tam

Author affiliations: University of Nottingham, Nottingham, UK (G.P. Dolan, R. Hale, J.S. Nguyen-Van-Tam); World Health Organization, Geneva, Switzerland (R.C. Harris, M. Mukaigawara, L. Stormont, Laura Béchard-Evans, Y.-S. Chao, S. Eremin, S. Martins, J.S. Tam, J. Peñalver); National Health Service Derbyshire County, Chesterfield, UK (M. Clarkson, R. Sokal); Health Protection Agency South West, Gloucester, UK (G. Morgan); Tokyo Medical Dental University, Tokyo, Japan (H. Horiuchi); and University of Bielefeld, Bielefeld, Germany (A. Zanuzdana)

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Table 4

Clinically defined outbreaks and clusters of ILI in a review of the vaccination of health care workers to protect patients at risk for acute respiratory disease*

Study Study design Method of assessment Measure of effect in patient population Effect estimate (95% CI)
Oshitani et al. (28) Prospective cohort Defined as ILI >10% of total resident population. Mandatory reporting by survey. OR, unadjusted facilities with >10 staff members vaccinated vs. those with <10 staff members vaccinated 0.30 (0.09–0.69)†
Stevenson et al. (37) Cross-sectional No definition provided. Reporting by survey. χ2 test for trend; logistic regression χ2 p = 0.03; logistic regression p = 0.08
Shugarman et al. (35) Cross-sectional Defined as >3 residents within a 72-h period with influenza-like symptoms, sudden onset of fever, or “feverishness” and >1 of the following respiratory symptoms; sore throat, runny nose, cough, or nasal congestion. Reporting by survey. OR, facilities with staff vaccination coverage >55% and patient vaccination coverage >89%, vs. those with lower coverage 0.39 (0.17–0.87)†

*ILI, influenza-like illness; OR, odds ratio. Boldface indicates statistical significance.
†p value not reported.

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