Volume 18, Number 8—August 2012
CME ACTIVITY
Vaccination of Health Care Workers to Protect Patients at Increased Risk for Acute Respiratory Disease
Gayle P. Dolan
, Rebecca C. Harris, Mandy Clarkson, Rachel Sokal, Gemma Morgan, Mitsuru Mukaigawara, Hiroshi Horiuchi, Rachel Hale, Laura Stormont, Laura Béchard-Evans, Yi-Sheng Chao, Sergey Eremin, Sara Martins, John S. Tam, Javier Peñalver, Arina Zanuzdana, and Jonathan S. Nguyen-Van-Tam
, Rebecca C. Harris, Mandy Clarkson, Rachel Sokal, Gemma Morgan, Mitsuru Mukaigawara, Hiroshi Horiuchi, Rachel Hale, Laura Stormont, Laura Béchard-Evans, Yi-Sheng Chao, Sergey Eremin, Sara Martins, John S. Tam, Javier Peñalver, Arina Zanuzdana, and Jonathan S. Nguyen-Van-TamTable 6
Measures of hospitalization in a review of the vaccination of health care workers to protect patients at risk for acute respiratory disease*
| Outcome measure and study | Study design | Method of assessment | Measure of effect in patient population | Effect estimate (95% CI) |
|---|---|---|---|---|
| Hospitalization | ||||
| Hayward et al. (27) | Cluster RCT | Reporting by lead nurse | Rate difference, epidemic period 1 | −0.02 (−0.05 to 0.02), p = 0.35 |
| Rate difference, epidemic period 2 | 0.00 (−0.03 to 0.04), p = 0.84 | |||
| Rate difference, nonepidemic period 1 | 0.00 (−0.04 to 0.03), p = 0.80 | |||
| Rate difference, nonepidemic period 2 | 0.00 (−0.03 to 0.03), p = 0.86 | |||
| Lemaitre et al. (26) | Cluster RCT | Not stated | OR | 1.03 (0.76–1.40), p = 0.85 |
| Thomas et al. (19) | Pooled data | OR, adjusted for clustering | 0.90 (0.66 to 1.21), p = 0.47 | |
| Hospitalization for respiratory causes: Lemaitre et al. (26) | Cluster RCT | Not stated | OR | 1.01 (0.43–2.34), p = 0.98 |
| Admissions to hospital with influenza-like illness: Hayward et al. (27) | Cluster RCT | Reporting by lead nurse | Rate difference, epidemic period 1 | −0.02 (−0.03 to 0.00), p = 0.009 |
| Rate difference, epidemic period 2 | 0.00 (−0.02 to 0.02), p = 0.99 | |||
| Rate difference, nonepidemic period 1 | −0.01 (−0.02 to 0.01), p = 0.32 | |||
| Rate difference, nonepidemic period 2 | 0.01 (0.00–0.02), p = 0.31 |
*RCT, randomized controlled trial; OR, odds ratio. Boldface indicates statistical significance. Shading indicates pooled data.
