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Volume 18, Number 8—August 2012

CME ACTIVITY

Vaccination of Health Care Workers to Protect Patients at Increased Risk for Acute Respiratory Disease

Gayle P. DolanComments to Author , Rebecca C. Harris, Mandy Clarkson, Rachel Sokal, Gemma Morgan, Mitsuru Mukaigawara, Hiroshi Horiuchi, Rachel Hale, Laura Stormont, Laura Béchard-Evans, Yi-Sheng Chao, Sergey Eremin, Sara Martins, John S. Tam, Javier Peñalver, Arina Zanuzdana, and Jonathan S. Nguyen-Van-Tam

Author affiliations: University of Nottingham, Nottingham, UK (G.P. Dolan, R. Hale, J.S. Nguyen-Van-Tam); World Health Organization, Geneva, Switzerland (R.C. Harris, M. Mukaigawara, L. Stormont, Laura Béchard-Evans, Y.-S. Chao, S. Eremin, S. Martins, J.S. Tam, J. Peñalver); National Health Service Derbyshire County, Chesterfield, UK (M. Clarkson, R. Sokal); Health Protection Agency South West, Gloucester, UK (G. Morgan); Tokyo Medical Dental University, Tokyo, Japan (H. Horiuchi); and University of Bielefeld, Bielefeld, Germany (A. Zanuzdana)

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Table 6

Measures of hospitalization in a review of the vaccination of health care workers to protect patients at risk for acute respiratory disease*

Outcome measure and study Study design Method of assessment Measure of effect in patient population Effect estimate (95% CI)
Hospitalization
Hayward et al. (27) Cluster RCT Reporting by lead nurse Rate difference, epidemic period 1 −0.02 (−0.05 to 0.02), p = 0.35
Rate difference, epidemic period 2 0.00 (−0.03 to 0.04), p = 0.84
Rate difference, nonepidemic period 1 0.00 (−0.04 to 0.03), p = 0.80
Rate difference, nonepidemic period 2 0.00 (−0.03 to 0.03), p = 0.86
Lemaitre et al. (26) Cluster RCT Not stated OR 1.03 (0.76–1.40), p = 0.85
Thomas et al. (19) Pooled data OR, adjusted for clustering 0.90 (0.66 to 1.21), p = 0.47
Hospitalization for respiratory causes: Lemaitre et al. (26) Cluster RCT Not stated OR 1.01 (0.43–2.34), p = 0.98
Admissions to hospital with influenza-like illness: Hayward et al. (27) Cluster RCT Reporting by lead nurse Rate difference, epidemic period 1 −0.02 (−0.03 to 0.00), p = 0.009
Rate difference, epidemic period 2 0.00 (−0.02 to 0.02), p = 0.99
Rate difference, nonepidemic period 1 −0.01 (−0.02 to 0.01), p = 0.32
Rate difference, nonepidemic period 2 0.01 (0.00–0.02), p = 0.31

*RCT, randomized controlled trial; OR, odds ratio. Boldface indicates statistical significance. Shading indicates pooled data.

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