Volume 18, Number 8—August 2012
CME ACTIVITY
Vaccination of Health Care Workers to Protect Patients at Increased Risk for Acute Respiratory Disease
Gayle P. Dolan
, Rebecca C. Harris, Mandy Clarkson, Rachel Sokal, Gemma Morgan, Mitsuru Mukaigawara, Hiroshi Horiuchi, Rachel Hale, Laura Stormont, Laura Béchard-Evans, Yi-Sheng Chao, Sergey Eremin, Sara Martins, John S. Tam, Javier Peñalver, Arina Zanuzdana, and Jonathan S. Nguyen-Van-Tam
, Rebecca C. Harris, Mandy Clarkson, Rachel Sokal, Gemma Morgan, Mitsuru Mukaigawara, Hiroshi Horiuchi, Rachel Hale, Laura Stormont, Laura Béchard-Evans, Yi-Sheng Chao, Sergey Eremin, Sara Martins, John S. Tam, Javier Peñalver, Arina Zanuzdana, and Jonathan S. Nguyen-Van-TamTable A3
Cases and consultation for laboratory-diagnosed influenza in a review of the vaccination of HCWs to protect patients at risk for acute respiratory disease*
| Outcome measure and study | Study design | Method of assessment | Measure of effect in patient population | Effect estimate (95% CI) |
|---|---|---|---|---|
| Laboratory-diagnosed influenza | ||||
| Carman et al. (24) | Cluster RCT | Nasal and oropharyngeal swabs (tissue culture/RT-PCR) | Difference in proportions | Routine surveillance, p = 0.42; opportunistic sampling, p = 0.54 |
| Thomas et al (19) | Pooled data† | OR, adjusted for clustering | 0.87 (0.38–1.99), p = 0.74 | |
| Weinstock et al. (32) | Ecologic | Clinical definition plus positive shell viral assay, enzyme immunoassay, or tissue culture | Difference in proportions (before to after implementation) | 72.1% decrease, p<0.01 |
| Engels et al. (31) | Ecologic | Nasopharyngeal aspirate culture | Difference in proportions (before to after implementation) | p<0.001, all children); p = 0.05, children with underlying disease; p<0.05, children <24 mos |
| Laboratory-diagnosed outbreaks of ILI, Monto et al. (36) | Cohort with case–control analysis | Laboratory confirmation of cases by using rapid antigen detection testing, viral cell culture, or RT-PCR | Difference in proportions | Median staff vaccination coverage in homes with outbreaks = 42% vs. 24% in homes without outbreaks, p>0.05 |
*HCW, health care worker; RCT, randomized controlled trial; RT-PCR, reverse transcription PCR; OR, odds ratio. Boldface indicates statistical significance. Shading indicates pooled data.
†Pooled by using data from Potter and Carman but no estimate of effect reported by Potter et al.
