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Volume 18, Number 8—August 2012

Dispatch

Autochthonous Infections with Hepatitis E Virus Genotype 4, France

Philippe ColsonComments to Author , Pauline Romanet, Valérie Moal, Patrick Borentain, Raj Purgus, Alban Benezech, Anne Motte, and René Gérolami
Author affiliations: Institut Hospitalo-Universitaire Méditerranée Infection, Marseille, France (P. Colson, P. Romanet, A. Motte); Aix-Marseille Université, Marseille (P. Colson); Hôpital Conception, Marseille (V. Moal, R. Purgus); and Centre Hospitalo-Universitaire Conception, Marseille (P. Borentain, A. Benezech, R. Gérolami)

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Table 1

Epidemiologic and virological findings for case-patients and contacts with HEV infection, Marseille, France, January–March 2011*

Case-patients and contacts, by ID no. Day obtained, serum sample (retrospectively tested sample) Anti-HEV IgG EIA result† Anti-HEV IgM result, by testing method
HEV RNA in serum (Ct) HEV genotype
EIA† Rapid test‡ Immunoblot
1 Feb18 10.3 14.2 Positive Positive Positive (29) 4
1a§ Mar 2 11.4 0.2 Negative Not tested Positive (38) NA
1a§ Mar 16 >10.0 2.0 Not tested Borderline Negative NA
1b¶ Mar 2 Negative Negative Negative Negative Negative NA
2 Mar 21 (Feb 7) 11.2 15.6 Positive Positive Positive (28) 4
2a# Mar 21 6.3 15.6 Positive Positive Negative NA
2b** Mar 21 0.1 Negative Negative Negative Negative NA
3 Jan 4 10.7 16.6 Positive Not tested Positive (27) 3f
4 Feb 3 (Jan 6) 5.2 6.3 Weakly reactive†† Positive Positive (26) 3c
5‡‡ Feb 3 0.1 1.6 Weakly reactive Negative Positive (31) 3f
6 Mar 1 11 14 Positive Positive Positive (38) NA
7 Mar 2 10.6 15.1 Positive Negative Positive (27) 3c
8‡‡ Mar 9 11.1 14.9 Positive Not tested Positive (28) 3c
9 Mar 18 10.5 16.4 Positive Not tested Positive (28) 3f
10‡‡ Mar 21 0.3 15.6 Positive Not tested Positive (24) 3c
11 Mar 23 1.2 13.8 Positive Positive Positive (27) 3f

*Italics indicate results for contacts of case-patients. HEV, hepatitis E virus; ID, identification; EIA, enzyme immunoassay; Ct, cycle threshold; NA, not applicable.
†EIA score represents test/cutoff optical density ratios.
‡An immunochromatographic rapid test.
§Contact (wife) of case-patient no. 1.
¶Contact (friend) of case-patient no. 1.
#Contact (friend) of case-patient no. 2.
**Contact (sister) of case-patient no. 2.
††Tested on a serum sample collected on March 3, 2011.
‡‡Kidney transplant recipient.

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