Volume 19, Number 1—January 2013
Dispatch
Linezolid Dependence in Staphylococcus epidermidis Bloodstream Isolates
Spyros Pournaras
, Eleni Ntokou, Olympia Zarkotou, Kyriaki Ranellou, Katerina Themeli-Digalaki, Constantinos Stathopoulos, and Athanassios Tsakris
, Eleni Ntokou, Olympia Zarkotou, Kyriaki Ranellou, Katerina Themeli-Digalaki, Constantinos Stathopoulos, and Athanassios Tsakris
Table 2
Characteristics of 8 linezolid-resistant Staphylococcus epidermidis isolates tested for growth in the presence and absence of linezolid, Greece, 2008–2010*
| Isolate designation | PFGE type | Mutations in each allele of the 23S rRNA |
MIC, μg/mL |
||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| rrlA | rrlB | rrlC | rrlD | rrlE | rrlF | Linezolid | Chloramphenicol | Clindamycin | |||
| A2562(1) | I | T2504A | – | T2504A | T2504A | T2504A | T2504A | >256 | >256 | >256 | |
| C2534T | – | C2534T | C2534T | C2534T | C2534T | ||||||
| A2570 | II | – | – | – | C2534T | C2534T | C2534T | 16 | >256 | >256 | |
| – | – | – | G2576T | G2576T | G2576T | ||||||
| E371 | I | T2504A | – | T2504A | T2504A | T2504A | T2504A | >256 | >256 | >256 | |
| C2534T | – | C2534T | C2534T | C2534T | C2534T | ||||||
| A2864 | I | T2504A | – | T2504A | T2504A | T2504A | T2504A | >256 | >256 | >256 | |
| C2534T | – | – | C2534T | C2534T | C2534T | ||||||
| 217 | I | C2534T | T2504A | – | T2504A | T2504A | T2504A | >256 | >256 | >256 | |
| – | C2534T | – | C2534T | – | C2534T | ||||||
| 605-2 | I | T2504A | – | – | T2504A | T2504A | T2504A | >256 | >256 | >256 | |
| – | – | – | C2534T | C2534T | C2534T | ||||||
| A1702 | II | G2576T | G2576T | G2576T | C2534T | G2576T | C2534T | 32 | 64 | >256 | |
| – | – | – | G2576T | – | G2576T | ||||||
| A2490 | III | C2356T | T2334C | – | C2356T | C2356T | C2356T | 32 | >256 | >256 | |
| G2576T | G2576T | – | G2576T | G2576T | G2576T | ||||||
*PFGE, pulsed-field gel electrophoresis; –, absence of mutated position in the respective 23S rRNA copy.
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