Skip directly to search Skip directly to A to Z list Skip directly to site content
CDC Home

Volume 19, Number 1—January 2013

Dispatch

Linezolid Dependence in Staphylococcus epidermidis Bloodstream Isolates

Spyros PournarasComments to Author , Eleni Ntokou, Olympia Zarkotou, Kyriaki Ranellou, Katerina Themeli-Digalaki, Constantinos Stathopoulos, and Athanassios Tsakris
Author affiliations: Author affiliations: University of Thessaly Medical School, Larissa, Greece (S. Pournaras, E. Ntokou); Tzaneio General Hospital, Piraeus, Greece (O. Zarkotou, K. Themeli-Digalaki); University of Athens Medical School, Athens, Greece (K. Ranellou, A. Tsakris); University of Patras School of Medicine, Patras, Greece (C. Stathopoulos)

Main Article

Table 2

Characteristics of 8 linezolid-resistant Staphylococcus epidermidis isolates tested for growth in the presence and absence of linezolid, Greece, 2008–2010*

Isolate designation PFGE type Mutations in each allele of the 23S rRNA
MIC, μg/mL
rrlA rrlB rrlC rrlD rrlE rrlF Linezolid Chloramphenicol Clindamycin
A2562(1) I T2504A T2504A T2504A T2504A T2504A >256 >256 >256
C2534T C2534T C2534T C2534T C2534T
A2570 II C2534T C2534T C2534T 16 >256 >256
G2576T G2576T G2576T
E371 I T2504A T2504A T2504A T2504A T2504A >256 >256 >256
C2534T C2534T C2534T C2534T C2534T
A2864 I T2504A T2504A T2504A T2504A T2504A >256 >256 >256
C2534T C2534T C2534T C2534T
217 I C2534T T2504A T2504A T2504A T2504A >256 >256 >256
C2534T C2534T C2534T
605-2 I T2504A T2504A T2504A T2504A >256 >256 >256
C2534T C2534T C2534T
A1702 II G2576T G2576T G2576T C2534T G2576T C2534T 32 64 >256
G2576T G2576T
A2490 III C2356T T2334C C2356T C2356T C2356T 32 >256 >256
G2576T G2576T G2576T G2576T G2576T

*PFGE, pulsed-field gel electrophoresis; –, absence of mutated position in the respective 23S rRNA copy.

Main Article

Top of Page

USA.gov: The U.S. Government's Official Web PortalDepartment of Health and Human Services
Centers for Disease Control and Prevention   1600 Clifton Rd. Atlanta, GA 30333, USA
800-CDC-INFO (800-232-4636) TTY: (888) 232-6348 - Contact CDC–INFO