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Volume 19, Number 1—January 2013

Letter

Cronobacter sakazakii ST4 Strains and Neonatal Meningitis, United States

Sumyya Hariri, Susan Joseph, and Stephen J. ForsytheComments to Author 
Author affiliations: Author affiliation: Nottingham Trent University School of Science and Technology, Nottingham, UK

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Table

Multilocus sequence typing of Cronobacter isolates received by the CDC during 2011*

Cronobacter species NTU strain ID no. CDC patient ID no. ST Location Isolation source Comment
C. sakazakii 1579 2012-05-05 4 Missouri CSF of <1 mo male, term infant; exposed to PIF Patient died
1566 2011-12-02 4 Ohio CSF of 1 mo male infant; exposed to PIF From twin of patient 2011-12-03
1567 2011-12-03 4 Ohio Feces of 1 mo male infant; exposed to PIF From twin of patient 2011-12-02; asymptomatic
1568 2011-12-04 4 Ohio Opened PIF Formula associated with 2011-12-02 and -03
1570 2011-21-01 4 Minnesota CSF of <1 mo male, term infant; exposed to PIF Brain infarction
1571 2011-21-03-01 4 Minnesota Opened PIF Formula associated with 2011-21-01
1576 2193-02 4 Michigan Tracheal secretion of <1 mo male, pre-term infant (30-wk EGA); not exposed to PIF Symptoms were not caused by Cronobacter infection. Fortified breast milk fed only after culture was obtained
1565 2011-12-01 107 Michigan CSF of <1 mo male, term infant; exposed to PIF Brain abscess; outcome unknown. Single locus variant of ST4
1572 2011-21-03-02 108 Minnesota Opened PIF Single locus variant of ST4
1577 2193-03 110 Illinois CSF of 1 mo female, term infant; exposed to PIF Triple locus variant of ST4
1578 2193-08-01 111 Illinois PIF reconstitution water Bottled water associated with 2193-03 case
1573 2011-18-05-02 8 Ohio Opened PIF Formula associated with 2011-18-01 and 2011-18-07
1574 2011-18-01 8 Ohio Feces of 4 mo female, term infant; exposed to PIF Diarrheal symptoms

1575
2011-18-07
8
Ohio
Feces of ≈5 mo female, term infant; exposed to PIF
Ongoing diarrhea; same patient as 2011-18-01
C. malonaticus 1569 2193-01 112 Wisconsin Blood of <1 mo male pre-term infant (32 week EGA); exposed to PIF Clinical meningitis; patient died

*NTU, Nottingham Trent University; ID, identification; CDC, Centers for Disease Control and Prevention; ST, sequence type; CSF, cerebrospinal fluid; PIF, powdered infant formula; EGA, estimated gestational age.

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