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Volume 19, Number 1—January 2013

Dispatch

Hepatitis E Virus Genotype 4 Outbreak, Italy, 2011

Anna R. Garbuglia, Paola Scognamiglio, Nicola Petrosillo, Claudio Maria Mastroianni, Pasquale Sordillo, Daniele Gentile, Patrizia La Scala, Enrico Girardi, and Maria R. CapobianchiComments to Author 
Author affiliations: Lazzaro Spallanzani National Institute for Infectious Diseases, Rome, Italy (A.R. Garbuglia, P. Scognamiglio, N. Petrosillo, P. La Scala, E. Girardi, M.R. Capobianchi); Sapienza University, Rome (C.M. Mastroianni); Santa Maria Goretti Hospital, Latina, Italy (C.M. Mastroianni); Tor Vergata University Polyclinic, Rome (P. Sordillo); and Local Health Unit ASL Roma H, Rome (D. Gentile)

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Table 1

Clinical and demographic characteristics of 5 case-patients involved in outbreak of HEV infection, Lazio, Italy, March–April 2011*

Characteristic Case-patient 1 Case-patient 2 Case-patient 3 Case-patient 4 Case-patient 5
HEV isolate no. E2104 E2105 E2107 E2111 E2115
Age, y/sex 60/M 38/M 66/M 57/M 74/M
Date of symptom onset Mar 10 Mar 12 Mar 14 Apr 1 Apr 2
Date of first HEV Ab detection Mar 19 Mar 23 Mar 25 Apr 11 Apr 14
Clinical signs, symptoms Fatigue, jaundice, dark urine General malaise, fatigue Fatigue, dark urine Jaundice Fatigue, vomiting
Duration of hospitalization, d 18 25 14 13 16
Alanine aminotransferase, IU/L† 4,017 2,648 2,648 5,163 3,001
Total bilirubin, mg/dL‡ 6.5 20.0 15.6 14.7 8.0
Hepatitis A virus IgG Positive Negative Negative Positive Positive
HBV surface antigen Negative Negative Negative Negative Negative
HBV core Ab Negative Negative Negative Positive Negative
Hepatitis C virus Ab Negative Negative Negative Negative Negative
HIV Ab Negative Negative Negative Negative Negative
Cytomegalovius IgM Negative Negative Negative Negative Negative
EBV EA IgG Negative Negative Negative Negative Negative
EBV VCA IgM Negative Negative Negative Negative Negative

*HEV, hepatitis E virus; Ab, antibody; HBV, hepatitis B virus; EBV, Epstein–Barr virus; EA, early antigen; VCA, viral capsid antigen.
†Reference range 7–34 IU/L.
‡Reference range 0.3–1.2 mg/dL.

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