Subclinical Avian Influenza A(H5N1) Virus Infection in Human, Vietnam
Mai Quynh Le , Peter Horby, Annette Fox, Hien Tran Nguyen, Hang Khanh Le Nguyen, Phuong Mai Vu Hoang, Khanh Cong Nguyen, Menno D. de Jong, Rienk E. Jeeninga, H. Rogier van Doorn, Jeremy Farrar, and Heiman F.L. Wertheim
Author affiliations: National Institute of Hygiene and Epidemiology, Hanoi, Vietnam (M.Q.Le, H.T. Nguyen, H.K.L. Nguyen, P.M.V. Hoang, K.C. Nguyen); Wellcome Trust Major Overseas Programme, Hanoi and Ho Chi Minh City, Vietnam (P. Horby, A. Fox, M.D. de Jong, H.R. van Doorn, J. Farrar, H.F.L. Wertheim); Centre for Tropical Medicine, Oxford, United Kingdom (P. Horby, A. Fox, H.R. van Doorn, J. Farrar, H.F.L. Wertheim); Academic Medical Center, Amsterdam, the Netherlands (M.D. de Jong, R.E. Jeeninga)
Figure. . Phylogentic analysis of avian influenza A(H5N1) virus clade 22.214.171.124 hemagglutinin DNA sequences from Vietnam compared with other isolates. Solid black box indicates isolate from the subclinical human case investigated in this study, A/CM32/2011; dashed boxes indicate sequences from Vietnam in 2011; gray shading indicates World Health Organization vaccine candidates A/common magpie/Hong Kong/5052/2007 and A/Hubei/1/2010 for clade 126.96.36.199. The sequences were downloaded from the Influenza Research Database (www.fludb.org), imported into MEGA 5.2 (www.megasoftware.net), and aligned by using MUSCLE (EMBL-EBI, Cambridgeshire, UK). The neighbor-joining tree was generated from the aligned sequences using standard settings. Scale bar indicates nucleotide substitutions per site.
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