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Volume 19, Number 11—November 2013

Dispatch

West Nile Virus, Texas, USA, 2012

Kristy O. MurrayComments to Author , Duke Ruktanonchai, Dawn Hesalroad, Eric Fonken, and Melissa S. Nolan
Author affiliations: Baylor College of Medicine, Houston, Texas, USA (K.O. Murray,, M.S. Nolan); Texas Children’s Hospital, Houston (K.O. Murray, M.S. Nolan); Texas Department of State Health Services, Austin, Texas, USA (D. Ruktanonchai, D. Hesalroad, E. Fonken)

Suggested citation for this article

Abstract

During the 2012 West Nile virus outbreak in Texas, USA, 1,868 cases were reported. Male patients, persons >65 years of age, and minorities were at highest risk for neuroinvasive disease. Fifty-three percent of counties reported a case; 48% of case-patients resided in 4 counties around Dallas/Fort Worth. The economic cost was >$47.6 million.

West Nile virus (WNV) first emerged in Texas, USA, in 2002 (1). Since then, the virus has become endemic, with ≈2,200 human cases reported in the state during 2002–2011 (2). In 2012, an unprecedented outbreak of WNV occurred in Texas; ≈1,900 cases were reported. The objective of this study was to understand the epidemiology of the 2012 WNV outbreak in Texas.

The Study

WNV infection is a reportable condition in Texas, with clinical cases passively reported by physicians to the local health departments, which in turn report to Texas Department of State Health Services (TxDSHS). We examined surveillance data for all reported cases for which symptom onset occurred during the 2012 calendar year, and we used descriptive statistics to describe the clinical features and demographic characteristics of reported case-patients. We calculated attack rates by sex, age, and race/ethnicity and incidence rates by county using population estimates for 2012 (3). Odds ratios (ORs), 95% CIs, and p values were calculated to determine differences in demographic variables between severe disease (WNV neuroinvasive disease [WNND], which included encephalitis, meningoencephalitis, and meningitis) and less severe disease (uncomplicated WNV fever). Epi Info 7.0 software (Centers for Disease Control and Prevention, Atlanta, GA, USA) was used for all statistical calculations.

Figure 1

Thumbnail of Number of reported West Nile virus cases, Texas, USA, 2012.

Figure 1. . Number of reported West Nile virus cases, Texas, USA, 2012.

A total of 1,868 cases were reported to TxDSHS during the 2012 transmission season (Table), including 844 (45%) WNND cases and 89 deaths (case-fatality rate 5%). Dates of onset ranged from May 1, 2012, through December 6, 2012 (Figure 1). The outbreak peaked during week 33 (mid-August) with 225 reported cases, which is historically the same peak for all reported WNV cases in Texas during 2002–2011 (2). The median time from date of symptom onset to date of official report to TxDSHS was 27 days (range 6–274 days).

When examining the demographic characteristics of the reported cases, we found significant differences in sex, age, and race/ethnicity with regard to severity of disease. Overall, a higher percentage of male case-patients were reported (55%), and male case-patients were significantly more likely than female case-patients to have WNND (OR 1.5, 95% CI 1.2–1.8, p<0.001). Median age of all case-patients was 54 years (range 1 month–100 years). As each age category increased, the attack rates also increased (Table). Persons >65 years of age were significantly more likely than younger persons to have WNND (OR 2.1, 95% CI 1.8–2.6, p<0.001). The median age of the 89 case-patients who died was 79 years (range 25–100 years). When examining race/ethnicity of all cases, we observed the highest attack rate (11.1 cases/100,000 population) in white, non-Hispanics. However, minority populations were significantly more likely to have WNND (OR 1.9, 95% CI 1.6–2.4, p<0.001).

Figure 2

Thumbnail of Incidence rates per 100,000 population during West Nile virus outbreak, Texas, USA, 2012. Numbers in parentheses indicate the number of counties that fell within each range.

Figure 2. . Incidence rates per 100,000 population during West Nile virus outbreak, Texas, USA, 2012. Numbers in parentheses indicate the number of counties that fell within each range.

Of the 254 counties in Texas, 135 (53%) reported a WNV case (Figure 2). The overall incidence rate for the state was 7.8 cases per 100,000 population. Almost half of the cases were reported from the northeastern quadrant of the state, including the Dallas/Fort Worth metroplex (902 [48%] cases): Dallas (396 [21%]), Tarrant (259 [14%]), Collin (64 [3%]), and Denton (183 [10%]) counties. These 4 counties had a combined incidence rate of 16 cases per 100,000 population.

Conclusions

The 2012 WNV outbreak in Texas was unexpected in terms of the magnitude of virus transmission and number of human cases. We recently observed a 3-year pattern of increases in reported human cases in Texas, as seen in 2003, 2006, and 2009 (2). In 2012, the dramatic epidemic was consistent with this prior observation, with the 1,868 reported cases being more than double the historic high, which occurred in 2003 (735 cases). In addition to the dramatic increase in human cases in 2012, the state also reported an increase in equine cases (121 cases in 2012 compared with 6 cases in 2011). The exact factors that contributed to this epidemic are unknown and most likely complex, considering that successful transmission depends on supportive environmental conditions, vector abundance, avian reservoir and susceptible host abundance, pathogenicity of the virus, and sizeable populations of immunologically naive reservoir species.

WNV more severely affects persons >65 years of age; deaths typically are reported in elderly presons (4,5). During 2012, there was some media speculation that more cases of severe disease occurred in younger persons and that the circulating strain of virus possibly was more pathogenic than in prior years. Compared with Texas data for 2002–2011, we did not find any statistically significant differences in median ages of reported WNND or fatal cases in 2012 using the Kruskal-Wallis 1-way analysis of variance on ranks. Our findings from 2012 remain consistent with our experience from prior years; however, it remains critical to emphasize the importance of recognizing disease and testing persons of any age who have clinical signs and symptoms consistent with WNV infection.

The 2012 WNV outbreak in Texas greatly affected the state economically. On the basis of the acute medical care and productivity loss cost estimates provided by Barber et al. (6) (adjusted to 2012 USD), we crudely estimate the 2012 outbreak in Texas cost ≈$47.6 million (range $14.5–$140.7 million; Technical Appendix Table [PDF - 136 KB - 1 page]). In addition to these acute costs, the outbreak also required an increase in resources for mosquito control and public health efforts to respond to the epidemic. A recent study reported the cost of aerial spraying alone in Dallas County exceeded $1.6 million (7). The long-term economic impact of this outbreak also is expected to be substantial as a consequence of long-term rehabilitation and disability costs (8), possible risk for chronic kidney disease (9), and risk for premature death in severe cases (10).

The unprecedented 2012 outbreak confirms the need for continued vigilance for surveillance to enable timely implementation of control measures to prevent virus transmission. We expect Texas will continue to experience endemic levels of virus transmission with periodic epizootics. Considering the economic and physical costs to persons severely affected, development of an effective vaccine is urgently needed to prevent disease. Until a vaccine becomes available, public health authorities will need to maintain their focus on surveillance, disease recognition, implementation of control measures, and public education about protective measures.

Dr Murray is the associate vice-chair for research and associate professor of pediatrics in the Department of Pediatrics and National School of Tropical Medicine at Baylor College of Medicine and Texas Children’s Hospital. Her research focuses on vector-borne and zoonotic diseases.

Acknowledgments

We thank Jim Schuermann, Nate Wolfe, and Alexandra Ingber for their assistance with data collection and preparation of this manuscript.

This project was generously supported in part by the Gillson Longenbaugh Foundation and the National Institutes of Health, National Institute of Allergy and Infectious Diseases (5R01AI091816-01).

References

  1. Lillibridge KM, Parsons R, Randle Y, Travassos da Rosa AP, Guzman H, Siirin M, The 2002 introduction of West Nile virus into Harris County, Texas, an area historically endemic for St. Louis encephalitis. Am J Trop Med Hyg. 2004;70:67681 .PubMed
  2. Nolan MS, Schuermann J, Murray KO. West Nile virus infection among humans, Texas, USA, 2002–2011. Emerg Infect Dis. 2013;19:1379. DOIPubMed
  3. Texas State Data Center. Texas Population Projections Program [cited 2013 May 20]. http://txsdc.utsa.edu/Data/TPEPP/Projections/Index.aspx
  4. Murray K, Baraniuk S, Resnick M, Arafat R, Kilborn C, Cain K, Risk factors for encephalitis and death from West Nile virus infection. Epidemiol Infect. 2006;134:132532. DOIPubMed
  5. Nash D, Mostashari F, Fine A, Miller J, O’Leary D, Murray K, The outbreak of West Nile virus infection in the New York City area in 1999. N Engl J Med. 2001;344:180714. DOIPubMed
  6. Barber LM, Schleier JJ III, Peterson RK. Economic cost analysis of West Nile virus outbreak, Sacramento County, California, USA, 2005. Emerg Infect Dis. 2010;16:4806. DOIPubMed
  7. Chung WMBC, Joyner SN, Hughes SM, Fomby TB, Luby JP, Haley RW. The 2012 West Nile encephalitis epidemic in Dallas, Texas. JAMA. 2013;310:297307. DOIPubMed
  8. Sejvar JJ, Haddad MB, Tierney BC, Campbell GL, Marfin AA, Van Gerpen JA, Neurologic manifestations and outcome of West Nile virus infection. JAMA. 2003;290:5115. DOIPubMed
  9. Nolan MS, Podoll AS, Hause AM, Akers KM, Finkel KW, Murray KO. Prevalence of chronic kidney disease and progression of disease over time among patients enrolled in the Houston West Nile virus cohort. PLoS ONE. 2012;7:e40374. DOIPubMed
  10. Lindsey NP, Sejvar JJ, Bode AV, Pape WJ, Campbell GL. Delayed mortality in a cohort of persons hospitalized with West Nile virus disease in Colorado in 2003. Vector Borne Zoonotic Dis. 2012;12:2305. DOIPubMed

Figures

Table

Technical Appendix

Suggested citation for this article: Murray KO, Ruktanonchai D, Hesalroad D, Fonken E, Nolan MS. West Nile virus, Texas, USA, 2012. Emerg Infect Dis [Internet]. 2013 Nov [date cited]. http://dx.doi.org/10.3201/eid1911.130768

DOI: 10.3201/eid1911.130768

Table of Contents – Volume 19, Number 11—November 2013

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Kristy O. Murray, Department of Pediatrics, National School of Tropical Medicine, 1102 Bates St, Suite 550, Houston, TX 77030, USA


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