Treatment Outcomes for Extensively Drug-Resistant Tuberculosis and HIV Co-infection
Max R. O’Donnell , Nesri Padayatchi, Charlotte Kvasnovsky, Lise Werner, Iqbal Master, and C. Robert Horsburgh
Author affiliations: Author affiliations: Albert Einstein College of Medicine, Bronx, New York, USA (M.R. O’Donnell); Centre for AIDS Programme of Research in South Africa, Durban, South Africa (M.R. O’Donnell, N. Padayatchi, L. Werner); University of Maryland School of Medicine, Baltimore, Maryland, USA (C. Kvasnovsky); King George V Hospital, Sydenham, South Africa (I. Master); Boston University School of Public Health, Boston, Massachusetts, USA (C.R. Horsburgh, Jr.); Boston University School of Medicine, Boston (C.R. Horsburgh, Jr.)
Figure 2. . A) Kaplan-Meier curves for sputum culture conversion for HIV-positive (dashed line) and HIV-negative (solid line) patients with extensively drug-resistant tuberculosis (XDR TB) receiving treatment, KwaZulu-Natal Province, South Africa. Sputum culture conversion is defined as 2 consecutive monthly TB cultures with no growth after 6 weeks of incubation after initiation of treatment (p = 0.706). p value was adjusted for age, initial smear result, and HIV status. B) Kaplan-Meier curves for patients receiving treatment for XDR TB stratified by sputum culture conversion status (p<0.0001). Solid line indicates conversion ≤2 months after initiation of treatment, dashed line indicates conversion >2 months after initiation of treatment, and top line with small and large dashes indicates no conversion. p values were adjusted for sex, TB treatment history, and HIV status. There was no significant difference between patients who showed culture conversion <2 months and >2 months after initiation of treatment (p = 0.5182).
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