Skip directly to site content Skip directly to page options Skip directly to A-Z link Skip directly to A-Z link Skip directly to A-Z link
Volume 19, Number 5—May 2013
Letter

Atypical Erythema Migrans in Patients with PCR-Positive Lyme Disease

Steven E. SchutzerComments to Author , Bernard W. Berger, James G. Krueger, Mark W. Eshoo, David J. Ecker, and John N. Aucott
Author affiliations: University of Medicine and Dentistry of New Jersey–New Jersey Medical School, Newark, New Jersey, USA (S.E. Schutzer); Private Dermatology Practice, Southampton, New York, USA (B.W. Berger); Rockefeller University, New York, New York, USA (J.G. Krueger); Ibis Biosciences Inc., Carlsbad, California, USA (M.W. Eshoo, D.J. Ecker); The Johns Hopkins School of Medicine, Baltimore, Maryland, USA (J.N. Aucott)

Main Article

Figure

Atypical erythema migrans lesion on a patient with PCR-positive result for Borrelia burgdorferi infection. The rash was not considered typical because it lacked central clearing and peripheral erythema. The differential diagnosis included a contact dermatitis and arthropod bite. At the initial examination, this patient was seronegative for B. burgdorferi by 2-tiered criteria. Three weeks after therapy, the patient had positive results for ELISA and IgM Western blot and negative results for IgG W

Figure. . Atypical erythema migrans lesion on a patient with PCR-positive result for Borrelia burgdorferi infection. The rash was not considered typical because it lacked central clearing and peripheral erythema. The differential diagnosis included a contact dermatitis and arthropod bite. At the initial examination, this patient was seronegative for B. burgdorferi by 2-tiered criteria. Three weeks after therapy, the patient had positive results for ELISA and IgM Western blot and negative results for IgG Western blot, providing evidence of seroevolution (i.e., increasing antibody titer and/or increase in band intensity or appearance of new antigen bands to B. burgdorferi).

Main Article

Page created: April 23, 2013
Page updated: April 23, 2013
Page reviewed: April 23, 2013
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
file_external