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Volume 19, Number 5—May 2013

Dispatch

Genetic Analysis of Primaquine Tolerance in a Patient with Relapsing Vivax Malaria

A. Taylor Bright1, Thamer Alenazi1, Sandra Shokoples, Joel Tarning, Giacomo M. Paganotti, Nicholas J. White, Stanley Houston, Elizabeth A. Winzeler, and Stephanie K. YanowComments to Author 
Author affiliations: University of California, San Diego, La Jolla, CA, USA (A.T. Bright, E.A. Winzeler); University of Alberta Hospital, Edmonton, Canada (T. Alenazi, S. Houston); King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia (T. Alenazi, S. Houston); Provincial Laboratory for Public Health, Edmonton, Canada (S. Shokoples, S.K. Yanow); Mahidol University, Bangkok, Thailand; University of Oxford, Oxford, UK (J. Tarning, N.J. White); “La Sapienza” University, Rome, Italy (G.M. Paganotti); University of Alberta, Edmonton, Canada (S.K. Yanow)

Main Article

Table

Genetic polymorphisms in drug-resistance genes from relapsing isolates of Plasmodium vivax *

Gene Chromosome Polymorphism Amino acid Reference Brazil EAC01 EAC02 EAC03
pvcrt 1 T330262C 5′ UTR T C C ND C
PVX_087980 T330482C 5′ UTR T T T T T
G330484T 5′ UTR G G G G G
C330495A 5′ UTR C C C C C
T331151C Intron T C C C C
T332453C Intron T C C ND C
A332874C Intron A C C ND C
G333391A Intron G G A A A
A333518G Intron A A G G G


T333544C
Intron
T
T
C
C
C
pvmrp 2 G153936A F1629 G G ND A A
PVX_097025 C154067T H1586Y C C C C C
G154391A V1478I G A ND A A
G154567C G1419A G G G G G
T154646G Y1393D T G ND G G
T154979A L1282I T T T T T


T155127G
I1232
T
T
ND
G
G
pvdhfr 5 C964763G S58R C A G G G
PVX_089950 T964796C Y69 T C T T T
G964939A S117N G A A A A
G964970A P127 G G A A A


A965106C
I173L
A
C
A
A
A
pvmdr1 10 C361917G K1393N C C C C G
PVX_080100 T362031C K1355 T T T T T
A362870G F1076L A A G G G
G363032A L1022 G G G G G
T363169A Y976F T T A A T
G363223A T958M G A A A A
T363374G M908L T G G G G
G363563A L845F G G G G G
C364004T G698S C C T T T
T364509C T529 T C C C C
A364557T S513R A A T T T


C364598T
D500N
C
T
C
C
C
pvdhps 14 G1256840A Intron G G A A A
PVX_123230 T1257042C P654 T T C C C
G1257064A A647V G G A A A
G1257856C A383G G C C C C
G1257859C S382C G C G G G
C1258389T M205I C T T T T
T1258579C E142G T T C C C

*UTR, untranslated region; ND, not determined

Main Article

1These authors contributed equally to this article.

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