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Volume 19, Number 6—June 2013

Synopsis

New Delhi Metallo-β-Lactamase–producing Enterobacteriaceae, United States

J. Kamile RasheedComments to Author , Brandon Kitchel, Wenming Zhu, Karen F. Anderson, Nancye C. Clark, Mary Jane Ferraro, Patrice Savard, Romney M. Humphries, Alexander J. Kallen, and Brandi M. Limbago
Author affiliations: Centers for Disease Control and Prevention, Atlanta, Georgia, USA (J.K. Rasheed, B. Kitchel, W. Zhu, K.F. Anderson, N.C. Clark, A.J. Kallen, B.M. Limbago); Massachusetts General Hospital, Boston, Massachusetts, USA (M.J. Ferraro); Johns Hopkins University, Baltimore, Maryland, USA (P. Savard); Johns Hopkins Health System, Baltimore (P. Savard); University of California Los Angeles David Geffen School of Medicine, Los Angeles, California, USA (R.M. Humphries)

Main Article

Table 3

Antimicrobial drug susceptibility profiles of NDM-producing isolates collected and Escherichia coli transformants, United States, April 2009–March 2011*

Isolate no. Organism MIC, µg/mL

Broth microdilution MBL screen result

Modified Hodge test result
TGC SXT CTX FEP ATM DOR ETP MER IMP IMP+EP† Ratio MBL ETP/MER
0S-506 Klebsiella pneumoniae ≤0.5 >8 >64 >32 >64 >8 >4 >8 >32 1 ≥64 + –/–
1100770 K. pneumoniae 2 >8 >64 >32 >64 >8 >4 >8 32 0.5 64 + +/–
1100975 K. pneumoniae 2 >8 >64 >32 >64 >8 >4 >8 32 1 32 + +/+
1100192 K. pneumoniae 1 >8 >64 >32 >64 >8 >4 >8 8 ≤0.5 ≥16 + +/–
1000527 K. pneumoniae >4 >8 >64 >32 >64 >8 >4 >8 >32 ≤0.5 >64 + +/+
1101459
K. pneumoniae
2
>8
>64
>32
>64
>8
>4
8
16

≤0.5
≥32
+

+/+
1101168
Salmonella enterica serovar Senftenberg
1
0.5
>64
>32
>64
8
>4
8
4

≤0.5
≥8
+

+/+
1100101 E. coli ≤0.5 >8 >64 >32 >64 >8 >4 >8 16 1 16 + +/–
1001728
E. coli
≤0.5
>8
>64
>32
16
>8
>4
>8
8

≤0.5
≥16
+

+/+
1000654
Enterobacter cloacae
>4
>8
>64
>32
>64
>8
>4
>8
>32

4
>8
+

+/+
0S-506 TF ≤0.5 ≤0.25 >64 16 64 4 4 4 4 ≤0.5 ≥8 + +/+
1100770 TF ≤0.5 ≤0.25 >64 32 32 4 8 4 4 ≤0.5 ≥8 + +/–
1100975 TF ≤0.5 ≤0.25 >64 16 32 4 4 4 2 ≤0.5 ≥4 + +/–
1100192 TF ≤0.5 ≤0.25 >64 16 ≤2 2 2 1 2 ≤0.5 ≥4 + +/+
1000527 TF ≤0.5 ≤0.25 >64 32 8 8 8 8 4 ≤0.5 ≥8 + +/+
1101459 TF ≤0.5 ≤0.25 >64 16 ≤2 4 4 4 4 ≤0.5 ≥8 + +/+
1101168 TF ≤0.5 ≤0.25 >64 16 ≤2 8 >8 8 8 ≤0.5 ≥16 + +/+
1100101 TF ≤0.5 ≤0.25 >64 >32 >64 >8 >8 16 8 ≤0.5 ≥16 + +/+
1001728 TF ≤0.5 ≤0.25 >64 32 32 8 8 8 8 ≤0.5 ≥16 + –/+
1000654
TF
≤0.5
>8
>64
>32
>64
>8
>8
32
32

≤0.5
≥64
+

+/+
Recipient E. coli DH-10BT1 ≤0.5 ≤0.25 ≤0.12 ≤0.5 ≤2 ≤0.12 ≤0.12 ≤0.12 ≤0.5 ≤0.5 ≤1 –/–

*NDM, New Delhi metallo-β-lactamase; ID, identification; MBL, Ambler class B metallo-β-lactamase; TGC, tigecycline; SXT, trimethoprim/sulfamethoxazole; CTX, cefotaxime; FEP, cefepime; ATM, aztreonam; DOR, doripenem; ETP, ertapenem; MER, meropenem; IMP, imipenem; EP, chelator; TF, transformant.
†IMP + EDTA + 1,10-phenanthroline, μg/mL.

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