Skip directly to search Skip directly to A to Z list Skip directly to site content
CDC Home

Volume 19, Number 8—August 2013

Dispatch

Primary and Secondary Human Bocavirus 1 Infections in a Family, Finland

Alma Jula, Matti Waris, Kalle Kantola, Ville Peltola, Maria Söderlund-Venermo, Klaus Hedman, and Olli RuuskanenComments to Author 
Author affiliations: Turku University Hospital, Turku, Finland (A. Jula, V. Peltola, O. Ruuskanen); University of Turku, Turku (M. Waris); University of Helsinki, Helsinki, Finland (K. Kantola, M. Söderlund-Venermo, K. Hedman)

Main Article

Table

HBoV1 DNA, other respiratory viruses, and HBoV antibodies in family members during 7 months, Finland*

Patient and no. days after hospital admission of index patient Symptoms of acute infection HBoV1 DNA in NPA, copies/mL HBoV1 DNA in serum, copies/mL† HBoV1 IgM‡ HBoV IgG avidity HBoV1 IgG‡ HBoV2 IgG‡ HBoV3 IgG‡§ Other viruses detected in NPA by PCR
Index
1 Yes 1.6 × 1010 NT NT NT NT NT NT None
4 Yes 4.1 × 108 3,000 2.148 2.0 1.034 0 0 HRV
9 Yes 3.0 × 105 1,400 2.089 2.0 3.127 0 0.034 HRV negative
29 Yes 300 440 1.613 9.7 3.028 0.060 0 HRV negative
64 No NT Negative 0.154 17.1 3.426 0.050 0 NT
74 No 5,400 NT NT NT NT NT NT None
109 Yes 600 Negative 0.040 31.3 3.221 0 0 PIV1
185 ND Negative NT NT NT NT NT NT NT
232
Yes
Negative
NT
NT
NT
NT
NT
NT
AdV
Twin brother
5 Yes 6,300 NT NT NT NT NT NT HRV
14 ND 7,800 NT NT NT NT NT NT HRV
29 ND 3,900 NT NT NT NT NT NT HRV
64 No NT Negative 0.022 26.9 3.305 0 0 None
74 No Negative NT NT NT NT NT NT None
109 Yes 99,000 Negative 0.011 38.2 3.242 0 0 PIV1
232
Yes
5,700
NT
NT
NT
NT
NT
NT
AdV
Mother
5 No Negative NT NT NT NT NT NT HRV
13 ND Negative NT 0.013 50.2 0 0.509 0.307 HRV negative
30 No Negative NT 0.019 45.0 0.001 0.542 0.360 HRV negative
64 No Negative NT 0.019 48.1 0.012 0.480 0.259 NT
109
No
300
NT
0.032
50.2
0
0.861
0.585
PIV1
Grandmother
5 Yes 5,100 NT NT NT NT NT NT None
13 ND 22,000 960 0.011 58.0 0.395 0.542 0.016 HRV negative
64 ND NT Negative 0.012 25.4 2.731 1.470 0 None
74 No 3,600 NT NT NT NT NT NT HRV negative
109 Yes 300 Negative 0.023 33.5 2.674 1.834 0 PIV1, HRV

*HBoV1, human bocavirus 1; NPA, nasopharyngeal aspirate; NT, not tested; HRV, human rhinovirus; HRV negative, tested by monoplex PCR only; PIV1, parainfluenzavirus type 1; ND, no data available; AdV, adenovirus; none, negative by multiplex PCR.
†All serum samples were negative for HBoV2–4 DNA (6).
‡HBoV antibodies after heterologous antigen competition are shown as absorbance values at 492 nm, cutoff 0.13 (7).
§IgG avidity was calculated as the ratio of 2 IgG end-point titers (urea positive/urea negative) as described (8). Results obtained with unblocked enzyme immunoassay and confirmed with specific competition enzyme immunoassays.

Main Article

Top of Page

USA.gov: The U.S. Government's Official Web PortalDepartment of Health and Human Services
Centers for Disease Control and Prevention   1600 Clifton Rd. Atlanta, GA 30333, USA
800-CDC-INFO (800-232-4636) TTY: (888) 232-6348 - Contact CDC–INFO