Divergent Astrovirus Associated with Neurologic Disease in Cattle
Linlin Li, Santiago Diab, Sabrina McGraw, Bradd Barr, Ryan Traslavina, Robert Higgins, Tom Talbot, Pat Blanchard, Guillermo Rimoldi, Elizabeth Fahsbender, Brady Page, Tung Gia Phan, Chunlin Wang, Xutao Deng, Patricia Pesavento , and Eric Delwart
Author affiliations: Blood Systems Research Institute, San Francisco, California, USA (L. Li, B. Page, T.G. Phan, X. Deng, E. Delwart); University of California San Francisco, San Francisco (L. Li, T.G. Phan, X. Deng, E. Delwart); University of California Davis, Davis, California, USA (S. Diab, S. McGraw, B. Barr, R. Traslavina, R. Higgins, P. Blanchard, G. Rimoldi, P. Pesavento); California Animal Health and Food Safety Laboratory, Davis (S. Diab, B. Barr, P. Blanchard, G. Rimoldi); Bishop Veterinary Hospital Inc., Bishop, California, USA (T. Talbot); University of South Florida, St. Petersburg, Florida, USA (E. Fahsbender); Stanford Genome Technology Center, Stanford, California, USA (C. Wang)
Figure 2. . Yearling steer with encephalomyelitis. Midsagittal section of brain and multiple transverse sections of cerebellum, brainstem, and spinal cord depicting the location and severity of microscopic lesions. Midsagittal section of the brain: red highlight indicates areas of the central nervous system affected, numbers indicate severity of the lesions (1 = least severe; 2 = more severe; 3 = most severe), and red lines (A, B, C, D) indicate the levels where transverse sections were cut. A, spinal cord. B, medulla oblongata. C, cerebellum and cerebellar peduncles. D, midbrain (superior colliculus). Cross-sections of brainstem, cerebellum, and spinal cord: red dots indicate sites and relative intensity of microscopic lesions.
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