Volume 2, Number 3—July 1996
Perspective
DNA Vaccines for Emerging Infectious Diseases: What If?
Table 1
Animal models of DNA vaccines
| Pathogen | Antigen | Animal Species | References |
|---|---|---|---|
| Bovine herpesvirus | Glycoprotein | Cattle, | mouse | (7) |
| Hepatitis B virus | Capsid (core antigen) | Mouse | (48) |
| Hepatitis B virus | Envelope protein (surface antigen) | Mouse Rabbit Rat Chimpanzee * | (3, 8-14, 53) |
| Hepatitis C virus | Core/Nucleocapsid | Mouse | (12, 15) |
| Herpes simplex virus | Glycoprotein B Glycoprotein D ICP27 | Mouse | * | (16-18) |
| Human immuno deficiency virus-1 | Envelope glycoprotein gp160 Noninfectious particles | Mouse Nonhuman primates | (19-22) |
| House dust mite | Allergen | Rat * | (52) |
| Influenza virus | Hemagglutinin Matrix protein Nucleoprotein | Chicken * Ferrets * Mouse * Nonhuman primates * | (23-29) |
| Leishmania major | Major surface glycoprotein | Mouse * | (50) |
| Lymphocytic choriomeningitis virus | Glycoprotein Nucleoprotein | Mouse | *@ | (30-32) |
| Mycobacterium tuberculosis | M. leprae hsp65 | Mouse | | (33) |
| Mycoplasma pulmonis | M. pulmonis DNA M. pulmonis DNA expression library | Mouse * | (34,35) |
| Papillomavirus | Major capsid protein L1 | Rabbit * | (51) |
| Plasmodium yoelii | Circumsporozoite protein | Mouse | | (36-38) |
| Rabies virus | Glycoprotein | Mouse * | (39-41) |
| Simian immunodeficiency virus | Env, gag | Monkeys | (49) |
| Schistosoma japonicum | Paramyosin (Sj97) | Mouse | (42) |
The symbols | and * refer to reports of partial or complete protection, respectively, to challenge by the infectious agent. In one case, enhanced immunopathology ( @ ) after intracranial viral challenge has been reported. (32).
Updated versions of this table can be found on The DNA Vaccine Web site (URL: http://www.genweb.com/Dnavax/Announce/table.html) where links are provided to the PubMed abstracts of most references. See also a compendium of recent articles on DNA vaccines in a special issue of the Annals of the New York Academy of Sciences, Volume 772 (New York Academy of Sciences Conference: "DNA Vaccines: A Novel Approach to Vaccination," Arlington, VA, April 7-9, 1995). The PubMed abstracts of the articles in this issue can be found on The DNA Vaccine Web.
