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Volume 20, Number 10—October 2014
Research

Person-to-Person Household and Nosocomial Transmission of Andes Hantavirus, Southern Chile, 2011

Constanza Martinez-Valdebenito, Mario Calvo, Cecilia Vial, Rita Mansilla, Claudia Marco, R. Eduardo Palma, Pablo Vial, Francisca Valdivieso, Gregory Mertz, and Marcela FerrésComments to Author 
Author affiliations: Pontificia Universidad Católica de Chile, Santiago, Chile (C. Martinez-Valdebenito, R.E. Palma, M. Ferrés); Universidad Austral de Chile, Valdivia, Chile (M. Calvo); Clínica Alemana–Universidad del Desarrollo, Santiago, Chile (C. Vial, C. Marco, P.A. Vial, F. Valdivieso); Secretaría Regional Ministerial, Valdivia, Chile (R. Mansilla); University of New Mexico, Albuquerque, New Mexico, USA (G. Mertz)

Main Article

Table 2

Clinical and epidemiologic features of 5 patients involved in outbreak of ANDV infection, Chile, 2011*

Feature Case-patient A† Case-patient B Case-patient C Case-patient D Case-patient E
Age, y/sex 73/M 31/F 53/F 60/F 34/M
Occupation Farmer Nursing assistant at hospital Teacher Cleaning personnel at hospital Car mechanic
Relationship to other case-patients
 Husband of case-patient C
 Health care provider for case-patient A
 Wife of case-patient A
 Health care assistant for case-patient A
 Husband of case-patient B
Date of symptom onset Feb 21 Mar 17 Mar 18 Mar 18 Apr 2
Date of hospitalization
 Feb 24
 Mar 20
 Mar 20
 Mar 22
 Apr 3
Signs and symptoms
Fever Yes Yes Yes Yes Yes
Respiratory symptoms‡ Yes Yes No Yes Yes
Gastrointestinal symptoms§ No No Yes Yes No
Other symptoms¶
 No
 Yes
 Yes
 Yes
 Yes
Mechanical ventilation, d 28 8 0 1 6
Hospitalization, d 30 22 12 1 17
Outcome
 Died
 Survived
 Survived
 Died
 Survived
Days from environmental exposure to onset of symptoms 16 25–26 41 7–45 41–42
Days from exposure to hantavirus case-patient to onset of symptoms
 NA
 19–21
 22–25
 18–20
 13–27
Laboratory test results on admission
Platelet count, × 103/μL 51 56 108 101 147
Leukocytes, × 103 cells/μL 4,67 5,46 1,21 3,92 11,46
Hematocrit, % 52 39 39 45 44
Lymphocytes, % 12 7 39 19 7
Immunoblasts, % Yes Yes Yes NR Yes
IgM/IgG for ANDV Negative# Positive Positive Positive Positive
RT-PCR ANDV in blood cells ND Positive Positive Positive Positive

*ANDV, Andes virus; NA, not applicable; NR, not reported; RT-PCR, reverse transcription PCR; ND, not done.
†Index case-patient.
‡Dry cough, dyspnea, cyanosis, crepitus.
§Vomiting, diarrhea, nausea.
¶Severe headache, meningeal signs, myalgia, arthralgia, conjunctival infection, chills, photophobia, facial edema.
#On hospital admission. Repeat testing after 24 days yielded positive results.

Main Article

Page created: September 12, 2014
Page updated: September 12, 2014
Page reviewed: September 12, 2014
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
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