Volume 20, Number 10—October 2014
Dispatch
Human Infection with Highly Pathogenic A(H7N7) Avian Influenza Virus, Italy, 2013
, Giada Rossini, Marzia Facchini, Gabriele Vaccari, Livia Di Trani, Angela Di Martino, Paolo Gaibani, Caterina Vocale, Giovanni Cattoli, Michael Bennett, John W. McCauley, Giovanni Rezza, Maria Luisa Moro, Roberto Rangoni, Alba Carola Finarelli, Maria Paola Landini, Maria Rita Castrucci, Isabella Donatelli, and the Influenza Task Force
Table 1
Comparison of the nucleotide sequences of highly pathogenic avian influenza A(H7N7) virus isolate from chickens and humans, Italy, August–September 2013*
| Virus, location (date)† | PB2 |
PB1 |
PA |
HA |
NP |
NA |
M |
|||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 232‡ | 279 | 333 | 1044 | 183‡ | 1882 | 2133 | 1251 | 471 | 1018‡ | 1410 | 72 | 515‡ | 541‡ | 1040‡ | 1347 | 818‡ | 884‡ | |||||||
| Chicken | ||||||||||||||||||||||||
| A/CK/4527, Ostellato (Aug 13)§ | C | T | T | C | C | C | C | G | A | G | G | G | A | T | C | A | A | G | ||||||
| A/CK/4541, Ostellato (Aug 13) | T | • | • | • | • | • | T | • | G | A | • | • | • | A | • | • | G | • | ||||||
| A/CK/4603, Mordano (Aug 19) | T | • | • | • | • | • | T | • | • | • | • | • | • | A | • | G | G | • | ||||||
| A/CK/4678, Portom (Aug 21) | T | • | • | T | • | • | T | • | • | • | • | A | • | A | • | G | G | • | ||||||
| A/CK/4774, Mordano (Aug 27) | T | • | C | • | • | T | T | • | • | • | A | • | • | A | • | • | • | • | ||||||
| A/CK/5091, Bondeno (Sep 2) | T | C | • | T | T | • | T | • | • | • | • | A | • | A | • | G | G | A | ||||||
| A/CK/5051,
Mordano
(Sep 3) |
T |
• |
• |
– |
• |
• |
T |
A |
• |
• |
• |
• |
• |
A |
• |
• |
• |
• |
||||||
| Human¶ | ||||||||||||||||||||||||
| 1, Mordano (Aug 29) | T | • | • | • | • | • | T | – | • | • | • | • | • | A | • | – | G | • | ||||||
| 2, Mordano (Sep 2) | T | • | • | • | • | • | T | – | • | • | • | • | • | A | • | • | • | • | ||||||
| 3, Mordano /Ostellato (Sep 7) | T | • | • | • | • | • | T | A | • | • | • | • | G# | A | A# | • | • | • | ||||||
*Dots indicate no nucleotide changes; –, notavailable. HA, hemagglutinin; NA, neuraminidase; NP, nucleocapsid protein; M, matrix; PA, polymerase acidic; PB, polymerase basic; Portom, Portomaggiore.
†Date indicates date collected. A/CK/4527, A/chicken/Italy/13VIR4527–11/2013; A/CK/4541, A/chicken/Italy/13VIR4541–34/2013; A/CK/4603, A/chicken/Italy/13VIR4603/2013; A/CK/4678, A/chicken/Italy/13VIR4678–1/2013; A/CK/4774, A/chicken/Italy/13VIR4774/2013; A/CK/5091, A/chicken/Italy/13VIR5091–1/2013; A/CK/5051, A/chicken/Italy/13VIR5051–3/2013.
‡Nonsynonymous substitution.
§First isolate from chicken (index case).
¶Clinical samples.
#Nucleotide changes found only in the specimen from patient 3 and responsible for the D172G and P347Q amino acid changes.
1Influenza Task Force members: Laura Calzoletti, Concetta Fabiani, Monica Meola, Annapina Palmieri, Arianna Boni, Guendalina Zaccaria (Istituto Superiore di Sanità, Rome); Marisa Cova, Valerio Parmeggiani, Claudio Po, Roberto Cagarelli, Gabriele Squintani, Emanuela Bedeschi (Emilia-Romagna Region, Bologna); and Maria Grazia Pompa (Ministry of Health, Rome).