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Volume 20, Number 12—December 2014
Dispatch

Evaluation of Commercially Available Serologic Diagnostic Tests for Chikungunya Virus

Christine M. PratComments to Author , Olivier Flusin, Amanda J. Panella, Bernard Tenebray, Robert Lanciotti, and Isabelle Leparc-Goffart
Author affiliations: French Armed Forces Biomedical Research Institute (IRBA), Marseille, France (C.M. Prat, O. Flusin, B. Tenebray, I. Leparc-Goffart); Centers for Disease Control and Prevention, Fort Collins, Colorado, USA (A. Panella, R. Lanciotti)

Main Article

Table 2

Results of serologic diagnostic testing of 23 serum samples (panel B) in a study evaluating the accuracy of commercially available CHIKV test kits*

IgM IgG IgM IgG IgM IgG IgM IgG
CHIKV
IgG
24 + NA NA NA NA NA + +
25 + NA NA NA NA NA + +
26 + NA NA NA NA NA +
27 + NA NA NA NA NA +
28 + NA NA NA NA NA +
29 + NA NA NA NA NA + +
IgM + IgG
30 + + NA NA NA NA NA + + NA NA
31 + + NA NA NA NA NA + + + +
32 + + NA NA NA NA NA + + + +
33 + + NA NA NA NA NA + +
34 + + NA NA NA NA NA + + +
35 + + NA NA NA NA NA + + +
36 + + NA NA NA NA NA +
37 + + NA NA NA NA NA + + +
38 + + NA NA NA NA NA + + +
39 + + NA NA NA NA NA + + + +
40 + + NA NA NA NA NA + + + NA
41 + + NA NA NA NA NA + + + +
IgM
42 + NA NA NA NA NA + + NA
43 + NA NA NA NA NA
44 + NA NA NA NA NA +
45 + NA NA NA NA NA + +
46 + NA NA NA NA NA
47
+


NA
NA
NA
NA
NA






DENV
IgM + IgG
48 NA NA NA NA NA
49 NA NA NA NA NA
50



NA
NA
NA
NA
NA





+
RVRV‡‡
IgG, 51

+

NA
NA
<10
NA
NA




NA
NA
MAYV‡‡
IgM + IgG, 52

+

NA
NA
<10







+
ONNV‡‡
IgM + IgG, 53 + + NA NA <10 + + + +

*The serum samples were obtained from IRBA (Marseille, France). CDC, Centers for Disease Control and Prevention; CHIKV, chikungunya virus; DENV, dengue virus; IRBA, French Armed Forces Biomedical Research Institute; MAYV, Mayaro virus; NA, not applicable; ONNV o’nyong-nyong virus; RDT, immunochromatography test for rapid detection; RVRV, Rift Valley fever virus.
†National Reference Center for Arboviruses at IRBA.
‡National Reference Center for Arboviruses at CDC (Fort Collins, CO, USA).
§Data are CHIKV neutralization titers of serum.
¶From Standard Diagnostics Inc., Yongin-si, South Korea.
#From CTK Biotech Inc., San Diego, CA, USA.
**From IBL International,Hamburg, Germany.
††From Euroimmun, Lübeck, Germany.
‡‡These samples were characterized by neutralization techniques against 4 viruses in parallel: RRV, MAYV, ONNV, and CHIKV.

Main Article

Page created: November 19, 2014
Page updated: November 19, 2014
Page reviewed: November 19, 2014
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
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