Volume 20, Number 2—February 2014
Dispatch
Replicative Capacity of MERS Coronavirus in Livestock Cell Lines
Isabella Eckerle, Victor M. Corman, Marcel A. Müller, Matthias Lenk, Rainer G. Ulrich, and Christian Drosten
Table
Characteristics of mammalian cell lines used in a study designed to narrow the search for the intermediate mammalian host of Middle East respiratory syndrome coronavirus
| Designation | Species of origin | Mammalian order | Organ of origin | Cell type |
|---|---|---|---|---|
| ZN-R | Goat (Capra hircus)* | Artiodactyla | Kidney | Primary |
| ZLu-R | Goat (C. hircus)* | Artiodactyla | Lung | Primary |
| LGK-1-R | Alpaca (Llama pacos)* | Artiodactyla | Kidney | Primary |
| TT-R.B | Arabian camel (Camelus dromedarius)*† | Artiodactyla | Umbilical cord | Immortalized |
| PO | Sheep (Ovis aries)* | Artiodactyla | Kidney | Immortalized |
| KN-R | Cattle (Bos taurus)* | Artiodactyla | Kidney | Primary |
| KLu-R | Cattle (B. taurus)* | Artiodactyla | Lung | Primary |
| MyglaAEC.B | Bank vole (Myodes glareolus)* | Rodentia | Trachea | Immortalized |
| Crocsu-Lu | Lesser white-toothed shrew (Crocidura suaveolens)* | Soricomorpha | Lung | Immortalized |
| PipNi | Common pipistrelle (Pipistrellus pipistrellus)* | Chiroptera | Kidney | Immortalized |
| A549 | Human (Homo sapiens) | Primates | Lung | Immortalized |
| Vero E6 | African green monkey (Chlorocebus aethiops) | Primates | Kidney | Immortalized |
*Species of origin was confirmed by sequencing of the cytochrome c subunit oxidase I gene.
†Parents and the calf phenotypically resembled C. bactrianus. The most likely explanation is cross-breeding between the 2 species with mitochondria stemming from a C. dromedarius mother in one of the former generations.
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Page updated: January 17, 2014
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