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Volume 20, Number 6—June 2014
CME ACTIVITY - Synopsis

Adverse Pregnancy Outcomes and Coxiella burnetii Antibodies in Pregnant Women, Denmark

Stine Yde NielsenComments to Author , Kåre Mølbak, Tine Brink Henriksen, Karen Angeliki Krogfelt, Carsten Schade Larsen, and Steen Villumsen
Author affiliations: Aarhus University Hospital, Aarhus, Denmark (S.Y. Nielsen, T.B. Henriksen, C.S. Larsen); Statens Serum Institut, Copenhagen, Denmark (K. Mølbak, K.A. Krogfelt, S. Villumsen)

Main Article

Table 1

Patient characteristics and pregnancy outcomes in 12 women who had positive Coxiella burnetii titers during pregnancy, Denmark*

Pt and preg no. Patient data
Fetal gestational age at delivery, wk + d Baby birth weight, g Clinical outcome of pregnancy C. burnetii test results
Age, y Parity Symptoms Animal contact Treatment during preg
Pt 1
33
2
Fever and cough first weeks of pregnancy
Yes, cattle, vet
Yes, from wk 15
38 + 6
3,570
Healthy baby
PCR urine wk 10 pos; bone marrow biopsy wk 15 neg; PCR breast milk, amniotic fluid, placenta neg
Pt 2†
40
1
Dry cough for weeks just before first pregnancy
Yes, cattle, vet
No
8 wk
NA
Miscarriage
NA
Pt 3
30
1
No
Yes, cattle, vet
Yes, from wk 10
39 + 1
3,500
Healthy baby
PCR placenta neg
Pt 4‡
34
1
No
Yes, cattle, vet
No
39 + 0
3,030
Single fetal death around wk 8; surviving twin with healthy outcome
PCR breast milk, placenta neg
Pt 5§
Preg 1 32 1 No Yes, cattle, vet
No 40 + 3 3,000 Dysmature baby NA
Preg 2
33
2
No
No
38 + 0
2,360
Caesarean, IUGR (23% from wk 28) and oligo

Pt 6
26
1
NA
Yes, cattle,
farmer
No
39
3,720
Healthy baby
PCR placenta
neg
Pt 7¶
32
1
No
Yes, cattle, vet
Yes, from wk 10
41
3,210
Acute caesarean due to uterine rupture
PCR placenta
neg
Pt 8
Preg 1 24 0 No Yes, cattle, assisting female farmer
No 27 + 2 NA IUGR, oligo/ malformations; baby died few hours postpartum NA
Preg 2
26
1
No
Yes, from wk 22
30
1,570
Preterm baby
PCR placenta
neg
Pt 9
Preg 1 30 0 No Yes, cattle, vet
From wk 20 39 + 4 3,790 Healthy baby PCR placenta, breast milk neg
Preg 2
33
1
No
No
40 + 2
4,170
Healthy baby
NA
Pt 10
Preg 1 30 0 1 mo dry cough at start of preg, short episode of fever Yes, cattle, vet
Yes, from wk 10 39 + 6 3,420 Healthy baby PCR placenta, breast milk neg
Preg 2
33
1
No
No
41 + 2
3,400
Healthy baby
NA
Pt 11
30
1
No
Yes, cattle, vet
No
40
4,230
Healthy baby
PCR placenta neg
Pt 12 31 1 No Yes, cattle, vet Yes, from wk 22 39 + 5 3,570 Healthy baby PCR placenta neg

*See Table 2 for specific titers. Pt, patient; preg, pregnancy; vet, veterinarian; NA, not applicable; IUGR, intrauterine growth restriction; oligo, oligohydramnion.
†Within 2 years, 3 spontaneous abortions and 1 extrauterine preg.
‡Q fever in 2006 (not pregnant).
§Acute Q fever in 2006 (not pregnant), treated with 3 wk doxycycline.
¶Two spontaneous abortions before this preg.

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Page created: May 14, 2014
Page updated: May 14, 2014
Page reviewed: May 14, 2014
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
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