Volume 20, Number 6—June 2014
CME ACTIVITY - Synopsis
Adverse Pregnancy Outcomes and Coxiella burnetii Antibodies in Pregnant Women, Denmark
Stine Yde Nielsen
, Kåre Mølbak, Tine Brink Henriksen, Karen Angeliki Krogfelt, Carsten Schade Larsen, and Steen Villumsen
, Kåre Mølbak, Tine Brink Henriksen, Karen Angeliki Krogfelt, Carsten Schade Larsen, and Steen Villumsen
Table 1
Patient characteristics and pregnancy outcomes in 12 women who had positive Coxiella burnetii titers during pregnancy, Denmark*
| Pt and preg no. | Patient data |
Fetal gestational age at delivery, wk + d | Baby birth weight, g | Clinical outcome of pregnancy | C. burnetii test results | ||||
|---|---|---|---|---|---|---|---|---|---|
| Age, y | Parity | Symptoms | Animal contact | Treatment during preg | |||||
| Pt 1 |
33 |
2 |
Fever and cough first weeks of pregnancy |
Yes, cattle, vet |
Yes, from wk 15 |
38 + 6 |
3,570 |
Healthy baby |
PCR urine wk 10 pos; bone marrow biopsy wk 15 neg; PCR breast milk, amniotic fluid, placenta neg |
| Pt 2† |
40 |
1 |
Dry cough for weeks just before first pregnancy |
Yes, cattle, vet |
No |
8 wk |
NA |
Miscarriage |
NA |
| Pt 3 |
30 |
1 |
No |
Yes, cattle, vet |
Yes, from wk 10 |
39 + 1 |
3,500 |
Healthy baby |
PCR placenta neg |
| Pt 4‡ |
34 |
1 |
No |
Yes, cattle, vet |
No |
39 + 0 |
3,030 |
Single fetal death around wk 8; surviving twin with healthy outcome |
PCR breast milk, placenta neg |
| Pt 5§ | |||||||||
| Preg 1 | 32 | 1 | No | Yes, cattle, vet |
No | 40 + 3 | 3,000 | Dysmature baby | NA |
| Preg 2 |
33 |
2 |
No |
No |
38 + 0 |
2,360 |
Caesarean, IUGR (23% from wk 28) and oligo |
||
| Pt 6 |
26 |
1 |
NA |
Yes, cattle,
farmer |
No |
39 |
3,720 |
Healthy baby |
PCR placenta
neg |
| Pt 7¶ |
32 |
1 |
No |
Yes, cattle, vet |
Yes, from wk 10 |
41 |
3,210 |
Acute caesarean due to uterine rupture |
PCR placenta
neg |
| Pt 8 | |||||||||
| Preg 1 | 24 | 0 | No | Yes, cattle, assisting female farmer |
No | 27 + 2 | NA | IUGR, oligo/ malformations; baby died few hours postpartum | NA |
| Preg 2 |
26 |
1 |
No |
Yes, from wk 22 |
30 |
1,570 |
Preterm baby |
PCR placenta
neg |
|
| Pt 9 | |||||||||
| Preg 1 | 30 | 0 | No | Yes, cattle, vet |
From wk 20 | 39 + 4 | 3,790 | Healthy baby | PCR placenta, breast milk neg |
| Preg 2 |
33 |
1 |
No |
No |
40 + 2 |
4,170 |
Healthy baby |
NA |
|
| Pt 10 | |||||||||
| Preg 1 | 30 | 0 | 1 mo dry cough at start of preg, short episode of fever | Yes, cattle, vet |
Yes, from wk 10 | 39 + 6 | 3,420 | Healthy baby | PCR placenta, breast milk neg |
| Preg 2 |
33 |
1 |
No |
No |
41 + 2 |
3,400 |
Healthy baby |
NA |
|
| Pt 11 |
30 |
1 |
No |
Yes, cattle, vet |
No |
40 |
4,230 |
Healthy baby |
PCR placenta neg |
| Pt 12 | 31 | 1 | No | Yes, cattle, vet | Yes, from wk 22 | 39 + 5 | 3,570 | Healthy baby | PCR placenta neg |
*See Table 2 for specific titers. Pt, patient; preg, pregnancy; vet, veterinarian; NA, not applicable; IUGR, intrauterine growth restriction; oligo, oligohydramnion.
†Within 2 years, 3 spontaneous abortions and 1 extrauterine preg.
‡Q fever in 2006 (not pregnant).
§Acute Q fever in 2006 (not pregnant), treated with 3 wk doxycycline.
¶Two spontaneous abortions before this preg.
Page created: May 14, 2014
Page updated: May 14, 2014
Page reviewed: May 14, 2014
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