Volume 21, Number 12—December 2015
Dispatch
Influenza A(H6N1) Virus in Dogs, Taiwan
Table 2
Gene, amino acid substitution | Virus |
Function | ||
---|---|---|---|---|
A/canine/Taiwan/E01/2014 | A/Taiwan/2/2013 | A/mallard/San-Jiang/275/2007 | ||
PB2 | ||||
E627K | K | E | E | Replication ability in mammalian host |
D701Q |
D |
D |
D |
Nuclear import |
PB1-F2 | ||||
N66S |
N |
Truncated form |
S |
Induction of apoptosis |
HA | ||||
Cleavage site | Single basic amino acid (PQIATR†G) | Single basic amino acid (PQIATR†G) | Single basic amino acid (PQIETR†G) | HA cleavage |
Q226L | Q | Q | Q | Increased virus binding ability of α2–6 sialic acid receptor |
G228S |
S |
S |
G |
|
NA | ||||
H275Y | H | H | H | Oseltamivir resistance |
41–52 and 68–69
deletions |
Deleted |
Deleted |
Complete |
Adaptation hallmark of waterfowl viruses to terrestrial poultry |
M2 | ||||
S31N |
N |
N |
S |
Adamantane resistance |
NS1 | ||||
D92E | D | D | D | Unknown |
EPEV sequence (C-terminus) | EPEV | EPEV | ESEV | PDZ ligand domain |
*PB, polymerase basic; HA, hemagglutinin; NA, neuraminidase; M, matrix; NS, nonstructural protein.
†HA cleavage site.
1These authors contributed equally to this article.
Page created: November 17, 2015
Page updated: November 17, 2015
Page reviewed: November 17, 2015
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