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Volume 21, Number 12—December 2015
Dispatch

Influenza A(H6N1) Virus in Dogs, Taiwan

Hui-Ting Lin1, Ching-Ho Wang1, Ling-Ling Chueh, Bi-Ling Su, and Lih-Chiann WangComments to Author 
Author affiliations: National Taiwan University, Taipei, Taiwan

Main Article

Table 2

Molecular characterization of A/canine/Taiwan/E01/2014 (H6N1) influenza virus and 2 other influenza viruses, Taiwan*

Gene, amino acid
substitution Virus
Function
A/canine/Taiwan/E01/2014 A/Taiwan/2/2013 A/mallard/San-Jiang/275/2007
PB2
E627K K E E Replication ability in mammalian host
D701Q
D
D
D
Nuclear import
PB1-F2
N66S
N
Truncated form
S
Induction of apoptosis
HA
Cleavage site Single basic amino acid (PQIATR†G) Single basic amino acid (PQIATR†G) Single basic amino acid (PQIETR†G) HA cleavage
Q226L Q Q Q Increased virus binding ability of α2–6 sialic acid receptor
G228S
S
S
G
NA
H275Y H H H Oseltamivir resistance
41–52 and 68–69 
deletions
Deleted
Deleted
Complete
Adaptation hallmark of waterfowl viruses to terrestrial poultry
M2
S31N
N
N
S
Adamantane resistance
NS1
D92E D D D Unknown
EPEV sequence (C-terminus) EPEV EPEV ESEV PDZ ligand domain

*PB, polymerase basic; HA, hemagglutinin; NA, neuraminidase; M, matrix; NS, nonstructural protein.
†HA cleavage site.

Main Article

1These authors contributed equally to this article.

Page created: November 17, 2015
Page updated: November 17, 2015
Page reviewed: November 17, 2015
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