Table 2

Naturally Acquired Antibodies against Haemophilus influenzae Type a in Aboriginal Adults, Canada

Eli B. Nix, Kylie Williams, Andrew D. Cox, Frank St. Michael, Sandra Romero-Steiner, Daniel S. Schmidt, William G. McCready, and Marina Ulanova

Author affiliations: Northern Ontario School of Medicine, Thunder Bay, Ontario, Canada (E.-B. Nix, K. Williams, W.G. McCready, M. Ulanova); National Research Council, Ottawa, Ontario, Canada (A.-D. Cox, F. St. Michael); Centers for Disease Control and Prevention, Atlanta, Georgia, USA (S. Romero-Steiner, D.S. Schmidt)

Main Article

Concentrations of antibodies against Haemophilus influenzae type a and type b and serum bactericidal assay titers in Aboriginal and non-Aboriginal patients in chronic renal failure and comparison groups of healthy persons from the Thunder Bay region, northwestern Ontario, Canada, 2010–2012*

Variable	Age-matched comparison groups of healthy Aboriginal persons and those with CRF		Aboriginal CRF patients		Non-Aboriginal CRF patients		Non-Aboriginal healthy comparison group age-matched to non-Aboriginal CRF	Age-matched comparison group regardless of race		CRF patients regardless of race
No. patients	30		30		30		30	60		60
Hia SBA GMT	268.1		147.0		49.64		104.0	167.0		85.43
95% CI	132.8–541.4		72.9–296.4		21.7–113.3		49.2–219.7	100–278.9		49.6–147.2
p value†		p = 0.22		p = 0.045		p = 0.18			p = 0.076
IgM against Hia, GMC	3.75		1.94		2.60		1.69	2.52		2.25
95% CI	2.28–6.15		1.08–3.50		1.69–4.01		0.95–3.01	1.72–3.69		1.57–3.21
p value		p = 0.086		p = 0.42		p = 0.23			p = 0.66
IgG against Hia, GMC	1.81		1.56		1.20		1.27	1.52		1.37
95% CI	1.26–2.60		1.12–2.17		0.89–1.63		0.91–1.77	1.19–1.93		1.10–1.71
p value		p = 0.53		p = 0.25		p = 0.81			p = 0.54
Hib SBA GMT	181.0		23.7		15.28		25.4	67.81		19.03
95% CI	84.0–390.2		11.09–50.62		6.88–33.94		11.26–57.30	37.21–123.6		11.12–32.56
P value		p = 0.0003		p = 0.42		p = 0.37			p = 0.002
IgM against Hib, GMC	0.11		0.04		0.08		0.04	0.07		0.06
95% CI	0.069–0.18		0.02–0.079		0.05–0.12		0.02–0.08	0.04–0.10		0.04–0.08
p value		p = 0.015		p = 0.10		p = 0.089			p = 0.64
IgG against Hib, GMC	1.63		0.61		0.62		0.87	1.19		0.61
95% CI	1.06–2.51		0.39–0.95		0.34–1.11		0.61–1.24	0.91–1.58		0.43–0.88
p value		p = 0.0018		p = 0.95		p = 0.31			p = 0.004

*CRF, chronic renal failure; Hia Haemophilus influenzae type a; SBA, serum bactericidal assay; GMT, geometric mean titer; GMC, geometric mean concentration (μg/mL); CI, confidence interval; Hib, Haemophilus influenzae type b.
†p values (Student t test [2-sided after log transformation]) are provided between each pairwise comparison. Significance level set at p<0.05; bold text indicates statistically significant p values.

Main Article

Page created: January 20, 2015

Page updated: January 20, 2015

Page reviewed: January 20, 2015

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