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Volume 21, Number 4—April 2015
Letter

Avian Influenza A(H10N7) Virus–Associated Mass Deaths among Harbor Seals

Rogier Bodewes, Theo M. Bestebroer, Erhard van der Vries, Josanne H. Verhagen, Sander Herfst, Marion Koopmans, Ron A.M. Fouchier, Vanessa M. Pfankuche, Peter Wohlsein, Ursula Siebert, Wolfgang Baumgärtner, and Albert D.M.E. OsterhausComments to Author 
Author affiliations: Erasmus Medical Centre, Rotterdam, the Netherlands (R. Bodewes, T.M. Bestebroer, E. van der Vries, J.H. Verhagen, S. Herfst, M.P. Koopmans, R.A.M. Fouchier, A.D.M.E. Osterhaus); University of Veterinary Medicine, Hannover, Germany (V.M. Pfankuche, P. Wohlsein, U. Siebert, W. Baumgärtner, A.D.M.E. Osterhaus); Artemis One Health, Utrecht, the Netherlands (A.D.M.E. Osterhaus)

Main Article

Figure

Histopathologic and phylogenetic analyses of necropsy samples from harbor seals infected with avian influenza A(H10N7) virus, Germany, 2014. A) Lung of harbor seal showing marked necrosis and sloughing of epithelial cells in bronchial glands (arrows); c = bronchial cartilage; hematoxylin and eosin stain. Scale bar indicates 50 μm B) Immunohistochemical labeling of influenza A nucleoprotein in bronchial epithelial cells (arrowheads) and glandular epithelial cells (arrows); c = bronchial cartilage

Figure. Histopathologic and phylogenetic analyses of necropsy samples from harbor seals infected with avian influenza A(H10N7) virus, Germany, 2014. A) Lung of harbor seal showing marked necrosis and sloughing of epithelial cells in bronchial glands (arrows); c = bronchial cartilage; hematoxylin and eosin stain. Scale bar indicates 50 μm B) Immunohistochemical labeling of influenza A nucleoprotein in bronchial epithelial cells (arrowheads) and glandular epithelial cells (arrows); c = bronchial cartilage; avidin-biotin-peroxidase complex method. Scale bar indicates 50 μm. C) Maximum-likelihood phylogenetic tree of the partial hemagglutinin gene (1,577 nt) of the influenza A/harbor seal/Germany/1/2014 (H10N7) isolate and various other closely related viruses. GenBank accession numbers are provided in Technical Appendix Table 1. Scale bar indicates nucleotide substitutions per site.

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Page created: March 17, 2015
Page updated: March 17, 2015
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