Volume 22, Number 10—October 2016
Research
Systematic Review and Meta-Analysis of Doxycycline Efficacy for Rectal Lymphogranuloma Venereum in Men Who Have Sex with Men
Table 2
Ref. | Method for selection of participants | Methods for measuring exposure and outcome variables | Design-specific sources of bias, excluding confounding | Method to control confounding | Statistical methods | Conflict of interest |
---|---|---|---|---|---|---|
(25) | + | + | NR | NR | + | NR |
(17) | + | + | + | NR | + | + |
(26) | + | + | ++ | NR | + | NR |
(28) | + | + | ++ | NR | + | NR |
(29) | + | + | ++ | NR | + | NR |
(30) | + | + | ++ | NR | + | NR |
(27) | + | + | ++ | NR | + | + |
(3) | + | + | NR | NR | + | + |
(31) | + | + | ++ | NR | + | NR |
*NR, not reported; ref., reference; +, low risk of bias; ++, moderate risk of bias; +++, high risk of bias.
References
- Macdonald N, Sullivan AK, French P, White JA, Dean G, Smith A, Risk factors for rectal lymphogranuloma venereum in gay men: results of a multicentre case-control study in the U.K. Sex Transm Infect. 2014;90:262–8.DOIPubMedGoogle Scholar
- Hughes G, Alexander S, Simms I, Conti S, Ward H, Powers C, ; LGV Incident Group. Lymphogranuloma venereum diagnoses among men who have sex with men in the U.K.: interpreting a cross-sectional study using an epidemic phase-specific framework. Sex Transm Infect. 2013;89:542–7.DOIPubMedGoogle Scholar
- Rodríguez-Domínguez M, Puerta T, Menéndez B, González-Alba JM, Rodríguez C, Hellín T, Clinical and epidemiological characterization of a lymphogranuloma venereum outbreak in Madrid, Spain: co-circulation of two variants. Clin Microbiol Infect. 2014;20:219–25.DOIPubMedGoogle Scholar
- Haar K, Dudareva-Vizule S, Wisplinghoff H, Wisplinghoff F, Sailer A, Jansen K, Lymphogranuloma venereum in men screened for pharyngeal and rectal infection, Germany. Emerg Infect Dis. 2013;19:488–92.DOIPubMedGoogle Scholar
- de Vries HJ, Zingoni A, Kreuter A, Moi H, White JA; European Branch of the International Union against Sexually Transmitted Infections; European Academy of Dermatology and Venereology; European Dermatology Forum; European Society of Clinical Microbiology and Infectious Diseases; Union of European Medical Specialists; European Centre for Disease Prevention and Control; European Office of the World Health Organisation. 2013 European guideline on the management of lymphogranuloma venereum. J Eur Acad Dermatol Venereol. 2015;29:1–6.DOIPubMedGoogle Scholar
- White J, O’Farrell N, Daniels D; British Association for Sexual Health and HIV. 2013 UK National Guideline for the management of lymphogranuloma venereum: Clinical Effectiveness Group of the British Association for Sexual Health and HIV (CEG/BASHH) Guideline development group. Int J STD AIDS. 2013;24:593–601.DOIPubMedGoogle Scholar
- Saxon C, Hughes G, Ison C; UK LGV Case-Finding Group. Asymptomatic lymphogranuloma venereum in men who have sex with men, United Kingdom. Emerg Infect Dis. 2016;22:112–6.DOIPubMedGoogle Scholar
- Bissessor M, Tabrizi SN, Bradshaw CS, Fairley CK, Hocking JS, Garland SM, The contribution of Mycoplasma genitalium to the aetiology of sexually acquired infectious proctitis in men who have sex with men. Clin Microbiol Infect. 2016;22:260–5.DOIPubMedGoogle Scholar
- Bissessor M, Fairley CK, Read T, Denham I, Bradshaw C, Chen M. The etiology of infectious proctitis in men who have sex with men differs according to HIV status. Sex Transm Dis. 2013;40:768–70.DOIPubMedGoogle Scholar
- Van der Bij AK, Spaargaren J, Morré SA, Fennema HS, Mindel A, Coutinho RA, Diagnostic and clinical implications of anorectal lymphogranuloma venereum in men who have sex with men: a retrospective case-control study. Clin Infect Dis. 2006;42:186–94.DOIPubMedGoogle Scholar
- Pallawela SN, Sullivan AK, Macdonald N, French P, White J, Dean G, Clinical predictors of rectal lymphogranuloma venereum infection: results from a multicentre case-control study in the U.K. Sex Transm Infect. 2014;90:269–74.DOIPubMedGoogle Scholar
- Stoner BP, Cohen SE. Lymphogranuloma venereum 2015: clinical presentation, diagnosis, and treatment. Clin Infect Dis. 2015;61(Suppl 8):S865–73.DOIPubMedGoogle Scholar
- de Vrieze NH, de Vries HJ. Lymphogranuloma venereum among men who have sex with men. An epidemiological and clinical review. Expert Rev Anti Infect Ther. 2014;12:697–704.DOIPubMedGoogle Scholar
- Greaves AB, Hilleman MR, Taggart SR, Bankhead AB, Feld M. Chemotherapy in bubonic lymphogranuloma venereum: a clinical and serological evaluation. Bull World Health Organ. 1957;16:277–89.PubMedGoogle Scholar
- Workowski KA, Bolan GA; Centers for Disease Control and Prevention. Sexually transmitted diseases treatment guidelines, 2015. MMWR Recomm Rep. 2015;64(RR-03):1–137.PubMedGoogle Scholar
- McLean CA, Stoner BP, Workowski KA. Treatment of lymphogranuloma venereum. Clin Infect Dis. 2007;44(Suppl 3):S147–52.DOIPubMedGoogle Scholar
- de Vries HJC, Smelov V, Middelburg JG, Pleijster J, Speksnijder AG, Morré SA. Delayed microbial cure of lymphogranuloma venereum proctitis with doxycycline treatment. Clin Infect Dis. 2009;48:e53–6.DOIPubMedGoogle Scholar
- Méchaï F, de Barbeyrac B, Aoun O, Mérens A, Imbert P, Rapp C. Doxycycline failure in lymphogranuloma venereum. Sex Transm Infect. 2010;86:278–9.DOIPubMedGoogle Scholar
- Castro R, Baptista T, Vale A, Nunes H, Prieto E, Araújo C, Lymphogranuloma venereum serovar L2b in Portugal. Int J STD AIDS. 2010;21:265–6.DOIPubMedGoogle Scholar
- Vall-Mayans M, Isaksson J, Caballero E, Sallés B, Herrmann B. Bubonic lymphogranuloma venereum with multidrug treatment failure. Int J STD AIDS. 2014;25:306–8.DOIPubMedGoogle Scholar
- Oud EV, de Vrieze NH, de Meij A, de Vries HJ. Pitfalls in the diagnosis and management of inguinal lymphogranuloma venereum: important lessons from a case series. Sex Transm Infect. 2014;90:279–82.DOIPubMedGoogle Scholar
- Higgins JP, Thompson SG, Deeks JJ, Altman DG. Measuring inconsistency in meta-analyses. BMJ. 2003;327:557–60.DOIPubMedGoogle Scholar
- Sterne JA, Sutton AJ, Ioannidis JP, Terrin N, Jones DR, Lau J, Recommendations for examining and interpreting funnel plot asymmetry in meta-analyses of randomised controlled trials. BMJ. 2011;343:d4002.DOIPubMedGoogle Scholar
- Sanderson S, Tatt ID, Higgins JP. Tools for assessing quality and susceptibility to bias in observational studies in epidemiology: a systematic review and annotated bibliography. Int J Epidemiol. 2007;36:666–76.DOIPubMedGoogle Scholar
- Waalboer R, van der Snoek EM, van der Meijden WI, Mulder PG, Ossewaarde JM. Analysis of rectal Chlamydia trachomatis serovar distribution including L2 (lymphogranuloma venereum) at the Erasmus MC STI clinic, Rotterdam. Sex Transm Infect. 2006;82:207–11.DOIPubMedGoogle Scholar
- Hill SC, Hodson L, Smith A. An audit on the management of lymphogranuloma venereum in a sexual health clinic in London, UK. Int J STD AIDS. 2010;21:772–6.DOIPubMedGoogle Scholar
- Foschi C, Marangoni A, D’Antuono A, Nardini P, Compri M, Bellavista S, Prevalence and predictors of Lymphogranuloma venereum in a high risk population attending a STD outpatients clinic in Italy. BMC Res Notes. 2014;7:225.DOIPubMedGoogle Scholar
- Pallawela S, Elgalib A, Almeida M, Annan T, Alexander S, Tong CYW, Three weeks of doxycycline is an effective treatment for rectal lymphogranuloma venereum. HIV Med. 2010;11(Suppl 1):75–6.
- Bissessor M. P1-S2.39: characteristics of lymphogranuloma venereum (LGV) infection among homosexual men in Melbourne. Sex Transm Infect. 2011;87:A139 .DOIGoogle Scholar
- Vas A, Leighton J, Saxon C, Lebar D, Stott C, Ahmad S, Audit of the clinical management of lymphogranuloma venereum in three inner-city genitourinary medicine clinics. Int J STD AIDS. 2013;24(Suppl 5):30.
- Blanco JL, Fuertes I, Bosch J, Gonzalez A, Vergara A, Camp R, Effective treatment of lymphogranuloma venereum (LGV) with 1g azithromycin administered weekly for 3 weeks in an HIV-infected population [CROI abstract 845]. Top Antivir Med. 2015;23(e-1):384.
- Batteiger BE, Tu W, Ofner S, Van Der Pol B, Stothard DR, Orr DP, Repeated Chlamydia trachomatis genital infections in adolescent women. J Infect Dis. 2010;201:42–51.DOIPubMedGoogle Scholar
- Kong FY, Tabrizi SN, Fairley CK, Vodstrcil LA, Huston WM, Chen M, The efficacy of azithromycin and doxycycline for the treatment of rectal chlamydia infection: a systematic review and meta-analysis. J Antimicrob Chemother. 2015;70:1290–7.DOIPubMedGoogle Scholar
- Chen MY, Read TRH, Leslie DE, Bissessor M. A couplet: a case of anal ulceration and another of inguinal swelling. Med J Aust. 2011;195:47–8.PubMedGoogle Scholar
- Somboonna N, Wan R, Ojcius DM, Pettengill MA, Joseph SJ, Chang A, Hypervirulent Chlamydia trachomatis clinical strain is a recombinant between lymphogranuloma venereum (L(2)) and D lineages. MBio. 2011;2:e00045–11. DOIPubMedGoogle Scholar
- Harris SR, Clarke IN, Seth-Smith HMB, Solomon AW, Cutcliffe LT, Marsh P, Whole-genome analysis of diverse Chlamydia trachomatis strains identifies phylogenetic relationships masked by current clinical typing. Nat Genet. 2012;44:413–9, S1.DOIPubMedGoogle Scholar
- de Vries HJC, Schim van der Loeff MF, Bruisten SM. High-resolution typing of Chlamydia trachomatis: epidemiological and clinical uses. Curr Opin Infect Dis. 2015;28:61–71.DOIPubMedGoogle Scholar
- Dukers-Muijrers NH, Speksnijder AG, Morré SA, Wolffs PF, van der Sande MA, Brink AA, Detection of anorectal and cervicovaginal Chlamydia trachomatis infections following azithromycin treatment: prospective cohort study with multiple time-sequential measures of rRNA, DNA, quantitative load and symptoms. PLoS One. 2013;8:e81236.DOIPubMedGoogle Scholar
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