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Volume 22, Number 12—December 2016
Research

Whole-Genome Characterization and Strain Comparison of VT2f-Producing Escherichia coli Causing Hemolytic Uremic Syndrome

Laura GrandeComments to Author , Valeria Michelacci, Roslen Bondì, Federica Gigliucci, Eelco Franz, Mahdi Askari Badouei, Sabine Schlager, Fabio Minelli, Rosangela Tozzoli, Alfredo Caprioli, and Stefano Morabito
Author affiliations: Istituto Superiore di Sanità, Rome, Italy (L. Grande, V. Michelacci, R. Bondi, F. Gigliucci, F. Minelli, R. Tozzoli, A. Caprioli, S. Morabito); National Institute for Public Health and the Environment, Bilthoven, the Netherlands (E. Franz); Faculty of Veterinary Medicine, Garmsar Branch, Islamic Azad University, Garmsar, Iran (M. Askari Badouei); Austrian Agency for Health and Food Safety, Graz, Austria (S. Schlager)

Main Article

Table 2

Characteristics of VT2f-producing Escherichia coli investigated in a comparative analysis of the virulence profile of strains isolated from humans with mild and severe disease and from the animal reservoir*

Source and strain Year isolated Serotype Phylotype MLST LEE adfO efa1 cif nleA nleB nleC Hly katP espP Intimin type
Human diarrhea
M856 2008 ONT:H6 B2 ST583 + + – + – + + – – – α-2
M858 2008 O125:H6 B2 ST583 + + – + – + – – – – α-2
M859 2009 O113:H6 B2 ST121 + + – + – – – – – – α-2
M884 2011 O96:H7 B2 ST28 + + – + + + – – – – β-2
M885 2011 O132:H34 B2 ST582 + + – – – + + – – – β-2
M900 2012 O145:H34 B2 ST722 + + – – – + – – – – ι
BCW5711 2012 O63:H6 B2 ST583 + + – + + – + – – – α-2
BCW5746 2012 O63:H6 B2 ST583 + + – + – – + – – – α-2
BCW5743 2012 O63:H6 B2 ST583 + + – + – – + – – – α-2
BCW5739 2012 O63:H6 B2 ST583 + + – + – – + – – – α-2
BCW5717
 2012
 O63:H6
 B2
 ST583
 +
 +
 –
 +
 –
 –
 +
 –
 –
 –
 α-2
Pigeon
ED360 1997 O45:H2 B1 ST20 + + – + + + + – – – β
ED361 1997 O75:H2 B1 ST20 + + – + + + + – – – β
ED363 1997 O4:H2 B1 UNK + + – + + + + – – – β
ED366 1997 ONT:H2 B1 ST2685 + + – + + + + – – – β
ED369 1997 O45:H2 B1 ST20 + + – + + + + – – – β
ED377 1997 O4:H2 B1 UNK + + – + + + + – – – β
ED430 2000 O45:H2 B1 ST20 + + – + + + + – – – β
ED444
 2000
 O128:H2
 B1
 ST20
 +
 +
 –
 +
 +
 +
 +
 –
 –
 –
 β
HUS
EF453 2013 O80:H2 B1 ST301 + + + – + + + + – + ξ
EF467 2013 O26:H11 B1 ST21 + + + + + + + + + + β
EF476 2014 O55:H9 B1 ST301 + + + – + + + + – + ξ

*Human samples were diarrheal or fecal samples from HUS cases and pigeon samples were feces from asymptomatic birds. LEE, locus of enterocyte effacement; MLST, multilocus sequence type; UNK, unknown; +, positive; –, negative.

Main Article

Page created: November 17, 2016
Page updated: November 17, 2016
Page reviewed: November 17, 2016
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