Volume 22, Number 12—December 2016
Dispatch
Hepatitis E Virus in 3 Types of Laboratory Animals, China, 2012–2015
Lin Wang, Yulin Zhang, Wanyun Gong, William Tianshi Song, and Ling Wang
Table 1
Characteristics of laboratory rabbits, monkeys, and pigs tested for hepatitis E virus, China, 2012–2015*
| Batch no. | Sampling year | Age | No. animals | Species | No. positive, PCR/antibodies against HEV |
Genotype | Acceptability, %‡ | ||
|---|---|---|---|---|---|---|---|---|---|
| Total | First sampling | Subsequent sampling† | |||||||
| 1 | 2012 | 3 wk | 10 | NZW | 0/0 | 0/0 | 0/0 | NA | 100 |
| 2 | 2012 | 6 wk | 16 | NZW | 0/0 | 0/0 | 0/0 | NA | 100 |
| 3 | 2012 | 2.5 y | 20 | CM | 0/18 | 0/18 | 0/0 | NA | 10 |
| 3 | 2012 | 2.5 y | 126 | RM | 0/9 | 0/9 | 0/0 | NA | 92.9 |
| 4 | 2013 | 7 wk | 21 | NZW | 0/3 | 0/3 | 0/0 | NA | 85.7 |
| 5 | 2013 | 7 wk | 43 | JW | 0/0 | 0/0 | 0/0 | NA | 100 |
| 6 | 2013 | 28 wk | 32 | JW | 0/4 | 0/4 | 0/0 | NA | 87.5 |
| 7 | 2014 | 12 wk | 92 | JW | 2/10 | 2/10 | 0/0 | 3 | 87.0 |
| 8 | 2015 | 4 wk | 6 | BMP | 0/5 | 0/5 | 0/0 | NA | 16.7 |
| 9 | 2015 | 12 wk | 42 | NZW | 1/2 | 1/2 | 0/0 | 3 | 92.9 |
| 10 | 2015 | 12 wk | 76 | JW | 6/13 | 4/4 | 2/9 | 3 | 75 |
*BMP, Bama miniature pig (Sus scrofa domestica); CM, cynomolgus monkey (Macaca fascicularis); HEV, hepatitis E virus; JW, Japanese white rabbit (Oryctolagus cuniculus); NA, not applicable; NZW, New Zealand white rabbit (Oryctolagus cuniculus); RM, rhesus monkey (Macaca mulatta).
†Animals had negative results for PCR or antibodies against HEV at week 1, but results became positive for samples collected in subsequent weeks.
‡An animal was considered acceptable for the HEV study when all test results remained negative for 4 consecutive weeks.
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