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Volume 22, Number 3—March 2016
Research

Underestimation of Invasive Meningococcal Disease in Italy

Chiara Azzari1Comments to Author , Francesco Nieddu1, Maria Moriondo1, Giuseppe Indolfi, Clementina Canessa, Silvia Ricci, Leila Bianchi, Daniele Serranti, Giovanni Maria Poggi, and Massimo Resti
Author affiliations: Anna Meyer Children’s University Hospital, Florence (C. Azzari, F. Nieddu, M. Moriondo, G. Indolfi, C. Canessa, S. Ricci, L. Bianchi, D. Serranti, G.M. Poggi, M. Resti); University of Florence Department of Health Sciences, Florence, Italy (C. Azzari, F. Nieddu, M. Moriondo, S. Ricci, D. Serranti, G.M. Poggi)

Main Article

Table 2

Description of 11 case-patients with postmortem diagnosis of invasive meningococcal disease included in a national register for molecular surveillance of invasive bacterial disease, Italy, 2007–2014*

Patient no.
 Sex
 Age at death
 Preexisting disease
 Cause of missing or incorrect diagnosis
 First diagnosis of cause of death
 Culture result
 rPCR result†
 Serogroup
1 F 20 y None Died before being admitted to hospital Sudden death Not performed Positive B
2 M 5 mo None Died before being admitted to hospital SIDS Not performed Positive C
3 M 17 y None Misdiagnosis: acute myeloid leukemia Acute myeloid leukemia Negative Positive C
4 F 5 mo None Died before being admitted to hospital Sepsis Not performed Positive B
5 M 6 y None Died <1 h after hospital admission Sepsis Not performed Positive Y
6 F 11 mo None Died before being admitted to hospital Sepsis Not performed Positive C
7 M 4 y None Died before being admitted to hospital Sepsis Not performed Positive B
8 M 15 y Previous meningitis at age 5 y Negative culture-based tests Sepsis Negative Positive Y
9 M 20 y Diabetes type I Negative culture-based tests Sepsis Negative Positive C
10 M 13 y None Died at hospital admission Sepsis Not performed Positive C
11 M 6 y None Died at hospital admission Sepsis Not performed Positive B

*SIDSs, sudden infant death syndrome; rPCR, real-time PCR.
†Of ctrA gene of Neisseria meningitidis.

Main Article

1These authors contributed equally to this article.

Page created: February 18, 2016
Page updated: February 18, 2016
Page reviewed: February 18, 2016
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