Volume 22, Number 3—March 2016
Dispatch
Signs or Symptoms of Acute HIV Infection in a Cohort Undergoing Community-Based Screening
Martin Hoenigl
, Nella Green, Martha Camacho, Sara Gianella, Sanjay R. Mehta, Davey M. Smith, and Susan J. Little
, Nella Green, Martha Camacho, Sara Gianella, Sanjay R. Mehta, Davey M. Smith, and Susan J. Little
Table 1
Comparison of AHI stage, characteristics of signs or symptoms, CD4+ cell count, and viral load between persons with signs or symptoms before and at the time of NAT versus persons without, San Diego, California, USA, 2007–2014*
| Characteristic |
Total no. persons |
Symptoms before NAT† |
Asymptomatic before NAT |
p value |
Ongoing symptoms at NAT |
Absence of symptoms at NAT |
p value |
|---|---|---|---|---|---|---|---|
| No. persons | 90 | 72 | 18 | 47 | 43 | ||
| Overall no. signs/symptoms in those symptomatic, median (IQR) | 5 (3–7); n = 84 | 5 (4–7) | 5 (2–6); n = 12 | NS | 6 (4–8) | 5 (3–6); n = 37 | NS |
| Duration of symptoms, d, median (IQR) | 9 (5–13); n = 79 | 10 (6–13); n = 67 | 4 (3–7); n = 12 | <0.01 | 11 (8–14); n = 43 | 6 (3–9); n = 36 | <0.01 |
| CD4+ cell count, cells/μL, median (IQR) | 435 (298–597) | 435 (302–586) | 448 (257–615) | NS | 424 (299–592) | 445 (295–610) | NS |
| Viral load, log10 RNA, median (IQR) | 5.4 (4.5–6.3) | 5.8 (4.8–6.4) | 4.5 (3.2–5.0) | <0.01 | 5.6 (4.8–6.4) | 5.0 (3.8–6.1) | 0.07 |
*AHI, acute HIV infection; IQR, interquartile range; NAT, nucleic acid amplification testing; NS, not significant.
†Most frequently observed signs or symptoms that occurred during the 14 days before NAT or were ongoing at the time of NAT were fatigue (53 persons, 59% of the study population), fever (51, 57%), myalgia (48, 53%), headache (41, 46%), night sweats (35, 39%), pharyngitis (32, 36%), and gastrointestinal symptoms (29, 32%).
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