Skip directly to site content Skip directly to page options Skip directly to A-Z link Skip directly to A-Z link Skip directly to A-Z link
Volume 22, Number 4—April 2016
Research

Lassa Virus Seroprevalence in Sibirilia Commune, Bougouni District, Southern Mali

Nafomon Sogoba, Kyle Rosenke, Jennifer Adjemian, Sory Ibrahim Diawara, Ousmane Maiga, Moussa Keita, Drissa Konaté, Abdoul Salam Keita, Ibrahim Sissoko, Matt Boisen, Diana Nelson, Darin Oottamasathien, Molly Millett, Robert F. Garry, Luis M. Branco, Sékou F. Traoré, Seydou Doumbia, Heinz Feldmann, and David SafronetzComments to Author 
Author affiliations: University of Sciences, Techniques and Technologies of Bamako, Bamako, Mali (N. Sogoba, S.I. Diawara, O. Maiga, M. Keita, D. Konaté, A.S. Keita, I. Sissoko, S.F. Traoré, S. Doumbia); National Institutes of Health, Hamilton, Montana, USA (K. Rosenke, H. Feldmann, D. Safronetz); National Institutes of Health, Bethesda, Maryland, USA (J. Adjemian); Corgenix Medical Corporation, Inc., Broomfield, Colorado, USA (M. Boisen, D. Nelson, D. Oottamasathien, M. Millett); Tulane School of Medicine, New Orleans, Louisiana, USA (R.F. Garry); Zalgen Labs LLC, Germantown, Maryland, USA (L.M. Branco); Public Health Agency of Canada, Winnipeg, Manitoba, Canada (D. Safronetz)

Main Article

Table 2

Lassa virus IgG seroprevalence by age group, in 3 villages, southern Mali, 2015

Age group, y
Village
Total no. 
positive/no. tested (%)
Bamba, no. postive/no. tested (%)
Banzana, no. positive/no. tested (%)
Soromba, no.
positive/no. tested (%)
0–5 18/48 (37.5) 2/40 (5) 12/37 (32.4) 32/125 (25.6)
6–10 15/36 (41.7) 5/40 (12.5) 16/45 (35.6) 36/121 (29.8)
11–20 12/37 (32.4) 4/37 (10.8) 20/43 (46.5) 36/117 (30.8)
21–40 24/42 (57.1) 9/39 (23.1) 12/36 (33.3) 45/117 (38.5)
>40 19/37 (51.3) 9/44 (20.5) 22/39 (56.4) 50/120 (41.7)

Main Article

References
  1. Frame  JD, Baldwin  JM Jr, Gocke  DJ, Troup  JM. Lassa fever, a new virus disease of man from West Africa. I. Clinical description and pathological findings. Am J Trop Med Hyg. 1970;19:6706 .PubMedGoogle Scholar
  2. Bausch  DG, Demby  AH, Coulibaly  M, Kanu  J, Goba  A, Bah  A, Lassa fever in Guinea: I. Epidemiology of human disease and clinical observations. Vector Borne Zoonotic Dis. 2001;1:26981. DOIPubMedGoogle Scholar
  3. Frame  JD. Clinical features of Lassa fever in Liberia. Rev Infect Dis. 1989;11(Suppl 4):S7839. DOIPubMedGoogle Scholar
  4. McCormick  JB, Fisher-Hoch  SP. Lassa fever. Curr Top Microbiol Immunol. 2002;262:75109. DOIPubMedGoogle Scholar
  5. Ogbu  O, Ajuluchukwu  E, Uneke  CJ. Lassa fever in West African sub-region: an overview. J Vector Borne Dis. 2007;44:111 .PubMedGoogle Scholar
  6. Monath  TP, Maher  M, Casals  J, Kissling  RE, Cacciapuoti  A. Lassa fever in the Eastern Province of Sierra Leone, 1970–1972. II. Clinical observations and virological studies on selected hospital cases. Am J Trop Med Hyg. 1974;23:11409 .PubMedGoogle Scholar
  7. Fisher-Hoch  SP, Tomori  O, Nasidi  A, Perez-Oronoz  GI, Fakile  Y, Hutwagner  L, Review of cases of nosocomial Lassa fever in Nigeria: the high price of poor medical practice. BMJ. 1995;311:8579. DOIPubMedGoogle Scholar
  8. McCormick  JB. Epidemiology and control of Lassa fever. Curr Top Microbiol Immunol. 1987;134:6978. DOIPubMedGoogle Scholar
  9. Monath  TP, Newhouse  VF, Kemp  GE, Setzer  HW, Cacciapuoti  A. Lassa virus isolation from Mastomys natalensis rodents during an epidemic in Sierra Leone. Science. 1974;185:2635. DOIPubMedGoogle Scholar
  10. Sogoba  N, Feldmann  H, Safronetz  D. Lassa fever in West Africa: evidence for an expanded region of endemicity. Zoonoses Public Health. 2012;59(Suppl 2):437. DOIPubMedGoogle Scholar
  11. Peterson  AT, Moses  LM, Bausch  DG. Mapping transmission risk of Lassa fever in West Africa: the importance of quality control, sampling bias, and error weighting. PLoS ONE. 2014;9:e100711. DOIPubMedGoogle Scholar
  12. Günther  S, Emmerich  P, Laue  T, Kuhle  O, Asper  M, Jung  A, Imported Lassa fever in Germany: molecular characterization of a new Lassa virus strain. Emerg Infect Dis. 2000;6:46676. DOIPubMedGoogle Scholar
  13. Dzotsi  EK, Ohene  SA, Asiedu-Bekoe  F, Amankwa  J, Sarkodie  B, Adjabeng  M, The first cases of Lassa fever in Ghana. Ghana Med J. 2012;46:16670 .PubMedGoogle Scholar
  14. Kouadio  L, Nowak  K, Akoua-Koffi  C, Weiss  S, Allali  BK, Witkowski  PT, Lassa virus in multimammate rats, Côte d’Ivoire, 2013. Emerg Infect Dis. 2015;21:14813. DOIPubMedGoogle Scholar
  15. Atkin  S, Anaraki  S, Gothard  P, Walsh  A, Brown  D, Gopal  R, The first case of Lassa fever imported from Mali to the United Kingdom, February 2009. Euro Surveill. 2009;14: pi. 19145.
  16. Safronetz  D, Lopez  JE, Sogoba  N, Traore  SF, Raffel  SJ, Fischer  ER, Detection of Lassa virus, Mali. Emerg Infect Dis. 2010;16:11236. DOIPubMedGoogle Scholar
  17. Safronetz  D, Sogoba  N, Lopez  JE, Maiga  O, Dahlstrom  E, Zivcec  M, Geographic distribution and genetic characterization of Lassa virus in sub-Saharan Mali. PLoS Negl Trop Dis. 2013;7:e2582. DOIPubMedGoogle Scholar
  18. Branco  LM, Grove  JN, Boisen  ML, Shaffer  JG, Goba  A, Fullah  M, Emerging trends in Lassa fever: redefining the role of immunoglobulin M and inflammation in diagnosing acute infection. Virol J. 2011;8:478. DOIPubMedGoogle Scholar
  19. Shaffer  JG, Grant  DS, Schieffelin  JS, Boisen  ML, Goba  A, Hartnett  JN, Lassa fever in post-conflict Sierra Leone. PLoS Negl Trop Dis. 2014;8:e2748. DOIPubMedGoogle Scholar
  20. Emmerich  P, Gunther  S, Schmitz  H. Strain-specific antibody response to Lassa virus in the local population of west Africa. J Clin Virol. 2008;42:404. DOIPubMedGoogle Scholar
  21. Manning  JT, Forrester  N, Paessler  S. Lassa virus isolates from Mali and the Ivory Coast represent an emerging fifth lineage. Front Microbiol. 2015;6:1037.
  22. Andersen  KG, Shapiro  BJ, Matranga  CB, Sealfon  R, Lin  AE, Moses  LM, Clinical sequencing uncovers origins and evolution of Lassa virus. Cell. 2015;162:73850. DOIPubMedGoogle Scholar
  23. McCormick  JB, Webb  PA, Krebs  JW, Johnson  KM, Smith  ES. A prospective study of the epidemiology and ecology of Lassa fever. J Infect Dis. 1987;155:43744. DOIPubMedGoogle Scholar
  24. Günther  S, Lenz  O. Lassa virus. Crit Rev Clin Lab Sci. 2004;41:33990. DOIPubMedGoogle Scholar
  25. Richmond  JK, Baglole  DJ. Lassa fever: epidemiology, clinical features, and social consequences. BMJ. 2003;327:12715. DOIPubMedGoogle Scholar
  26. Khan  SH, Goba  A, Chu  M, Roth  C, Healing  T, Marx  A, New opportunities for field research on the pathogenesis and treatment of Lassa fever. Antiviral Res. 2008;78:10315. DOIPubMedGoogle Scholar
  27. Schoepp  RJ, Rossi  CA, Khan  SH, Goba  A, Fair  JN. Undiagnosed acute viral febrile illnesses, Sierra Leone. Emerg Infect Dis. 2014;20:117682. DOIPubMedGoogle Scholar
  28. Boisen  ML, Schieffelin  JS, Goba  A, Oottamasathien  D, Jones  AB, Shaffer  JG, Multiple circulating infections can mimic the early stages of viral hemorrhagic fevers and possible human exposure to filoviruses in Sierra Leone prior to the 2014 outbreak. Viral Immunol. 2015;28:1931. DOIPubMedGoogle Scholar
  29. Safronetz  D, Strong  JE, Feldmann  F, Haddock  E, Sogoba  N, Brining  D, A recently isolated Lassa virus from Mali demonstrates atypical clinical disease manifestations and decreased virulence in cynomolgus macaques. J Infect Dis. 2013;207:131627. DOIPubMedGoogle Scholar
  30. Gire  SK, Stremlau  M, Andersen  KG, Schaffner  SF, Bjornson  Z, Rubins  K, Epidemiology. Emerging disease or diagnosis? Science. 2012;338:7502. DOIPubMedGoogle Scholar
  31. Ter Meulen  J, Lukashevich  I, Sidibe  K, Inapogui  A, Marx  M, Dorlemann  A, Hunting of peridomestic rodents and consumption of their meat as possible risk factors for rodent-to-human transmission of Lassa virus in the Republic of Guinea. Am J Trop Med Hyg. 1996;55:6616 .PubMedGoogle Scholar
  32. Yalley-Ogunro  JE, Frame  JD, Hanson  AP. Endemic Lassa fever in Liberia. VI. Village serological surveys for evidence of Lassa virus activity in Lofa County, Liberia. Trans R Soc Trop Med Hyg. 1984;78:76470. DOIPubMedGoogle Scholar
  33. Kernéis  S, Koivogui  L, Magassouba  N, Koulemou  K, Lewis  R, Aplogan  A, Prevalence and risk factors of Lassa seropositivity in inhabitants of the forest region of Guinea: a cross-sectional study. PLoS Negl Trop Dis. 2009;3:e548. DOIPubMedGoogle Scholar
  34. Tomori  O, Fabiyi  A, Sorungbe  A, Smith  A, McCormick  JB. Viral hemorrhagic fever antibodies in Nigerian populations. Am J Trop Med Hyg. 1988;38:40710 .PubMedGoogle Scholar
  35. Keenlyside  RA, McCormick  JB, Webb  PA, Smith  E, Elliott  L, Johnson  KM. Case-control study of Mastomys natalensis and humans in Lassa virus–infected households in Sierra Leone. Am J Trop Med Hyg. 1983;32:82937 .PubMedGoogle Scholar

Main Article

Page created: March 15, 2016
Page updated: March 15, 2016
Page reviewed: March 15, 2016
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
file_external