Volume 22, Number 6—June 2016
CME ACTIVITY - Synopsis
Infectious Disease Risk Associated with Contaminated Propofol Anesthesia, 1989–20141
Table 3
Object† and study, year (reference) | Country | Antimicrobial agents‡ | Hospital unit§ | Crude % contaminated propofol (no. contaminated/no. tested) |
---|---|---|---|---|
Syringes | ||||
Farrington et al., 1994 (31) | United Kingdom | No | ICU | 6.0 (3/50) |
Bach et al., 1997 (30) | Germany | No | OR | 4.8 (8/168),¶ 5.1 (19/376)# |
Webb et al., 1998 (23) | Australia | ND | ICU | 5.9 (18/302) |
Total |
5.4 (48/896)** |
|||
Vials | ||||
McHugh et al., 1995 (25) | New Zealand | No | OR | 6.3 (16/254) |
Soong et al., 1999 (24) | Australia | ND | OR | 3.0 (3/100) |
Zorrilla-Vaca et al., 2014 (32) | Colombia | No | OR | 6.1 (12/198) |
Total |
5.6 (31/552)** |
|||
Infusion systems | ||||
Bach et al., 1997 (30) | Germany | No | ICU | 4.5 (10/224),¶ 1.6 (5/318)# |
Lorenz et al., 2002 (26) | Austria | No | OR | 11.3 (9/80),†† 8.8 (7/80)‡‡ |
Total |
4.4 (31/702)** |
|||
IV stopcock dead spaces | ||||
Cole et al., 2013 (27) | United States | Yes | OR | 17.3 (26/150) |
*ICU, intensive care unit; OR, operating room; ND, not described in publication; IV, intravenous.
†Clinical object from which residual propofol was taken to be cultured after clinical use.
‡Use of propofol formulations with antimicrobial additives.
§Hospital unit where the studies were conducted.
¶Results of a first study period during February 1–October 31, 1992.
#Results of a second study-period from December 1, 1994, through March 31, 1995.
**Total crude percentage of contaminated propofol for each kind of object (syringes, vials, infusion systems).
††Proportion of propofol contaminated, following the manufacturer’s handling recommendations.
‡‡Proportion of propofol contaminated, following a modified propofol handling protocol. (i.e., refilling empty syringes and renewing only the infusion line to the patient).
1Part of this work was presented at the XXXI Colombian Congress of Anesthesiology and Critical Care, Cali, Columbia, July 2015.