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Volume 22, Number 8—August 2016
Research

Middle East Respiratory Syndrome Coronavirus Transmission in Extended Family, Saudi Arabia, 2014

M. Allison Arwady, Basem M. Alraddadi, Colin Basler, Esam I. Azhar, Eltayb Abuelzein, Abdulfattah I. Sindy, Bakr M. Bin Sadiq, Abdulhakeem O. Althaqafi, Omaima Shabouni, Ayman Banjar, Lia M. Haynes, Susan I. Gerber, Daniel R. Feikin, and Tariq A. MadaniComments to Author 
Author affiliations: Centers for Disease Control and Prevention, Atlanta, Georgia, USA (M.A. Arwady, C. Basler, L.M. Haynes, S.I. Gerber, D.R. Feikin); King Faisal Specialist Hospital and Research Center, Jeddah (B. Alraddadi); Ministry of Health, Jeddah, Saudi Arabia (B. Alraddadi, E.I. Azhar, E. Abuelzein, A.I. Sindy, B.M. Bin Sadiq, A.O. Althaqafi, O. Shabouni, A. Banjar, T.A. Madani); King Abdulaziz University, Jeddah (E.I. Azhar, T.A. Madani); Ministry of National Guard, Jeddah (A.O. Althaqafi)

Main Article

Table 1

Clinical and laboratory characteristics of 19 family members who received a MERS-CoV diagnosis, Al-Qouz, Saudi Arabia, 2014*

Patient Age, y/sex Underlying condition Symptoms
 Hospitalization
 Disposition Test result
Presenting Onset date Admission date Intubated rRT-PCR† Antibody‡
A 32/M None Fever, cough, diarrhea Apr 18 Apr 21 No Discharged Apr 28 Neg: Apr 21, Apr 23, Apr 24, Jun 5 ELISA >6,400;
IFA pas; MNT 80
B 70/M HTN Fever, cough, diarrhea, shortness of breath May 1 May 1 No Discharged May 7 Neg: May 2, Jun 5 ELISA>6,400;
IFA pos; MNT 320
C 54/M DM, HTN, CAD Fever, shortness of breath May 6 May 9 Yes Discharged Jun 23 Pos: May 20 Not tested
D 65/M None Fever, abdominal distention, night sweats May 9 May 18 No Discharged May 21 Pos: May 20
Neg: Jun 5 ELISA >6,400; IFA pos; MNT 320
E 34/M None Fever, cough, shortness of breath May 14 May 17 No Discharged May 30 Pos: May 21
Neg: Jun 5 ELISA >6,400; IFA pos; MNT 160
F 50/F HTN, CAD Diarrhea, fever, cough, headache May 17 May 21 Yes Died May 31 Pos: May 22 Not tested
G 29/M DM Abdominal pain, diarrhea May 20 May 21 No Discharged May 26 Neg: May 22, Jun 5 ELISA >6,400; IFA pos; MNT 160
H 16/M None Fever, cough, sore throat, diarrhea May 20 May 21 No Discharged May 26 Neg: May 22, Jun 5 ELISA 6,400; IFA pos; MNT 40
I 48/M DM, HTN Fever, cough, shortness of breath May 21 May 26 Yes Discharged Jul 1 Neg; May 27
Pos: May 29 Not tested
J 39/M DM, HTN Fever, cough, sore throat, chest pain May 22 May 27 Yes Discharged Jul 1 Pos: May 28 Not tested
K 73/M DM, HTN, CAD Fever, cough, hypoglycemia Jun 4 Jun 6 Yes Died Jun 20 Pos: Jun 9 Not tested
L 27/M None Tested as a contact; no symptoms None No medical care No Well Pos: May 22
Neg: Jun 5 Not tested
M 25/M None Tested as a contact; cough Unknown No medical care No Well Pos: May 23
Neg: Jun 5 ELISA >6,400; IFA pos; MNT 20
N 2/M None Tested as a contact; fever Unknown ED care, not admitted No Well Pos: May 25
Neg: Jun 5 Not tested
O 36/M None Tested as a contact; subjective fever Jun 6 No medical care No Well Pos: Jun 11 Not tested
P 50/F None Tested as a contact; no symptoms None No medical care No Well Neg: once during May 20–29, Jun 5 ELISA >6,400; IFA pos; MNT <20
Q 38/M Asthma Tested as a contact; no symptoms None No medical care No Well Neg: once during May 20–29; Jun 5 ELISA 1,600; IFA pos; MNT 40
R 29/M None Fever, cough, diarrhea Unknown ED care, not admitted No Well Neg: once during May 20–29, Jun 5 ELISA 400; IFA indeterminate; MNT 20
S 34/F None Fever, cough, sore throat, diarrhea, shortness of breath Unknown ED care, not admitted No Well Neg: once during May 20–29, Jun 5 ELISA >6,400; IFA pos; MNT 20

*CAD, coronary artery disease; DM, diabetes mellitus; ED, emergency department; HTN, hypertension; IFA, immunofluorescence assay; MERS-CoV, Middle East respiratory syndrome coronavirus; MNT, microneutralization testing; neg, negative; pos, positive; rRT-PCR, real-time reverse transcription PCR.
†Initial rRT-PCR for all persons was conducted at the time of illness (or among asymptomatic persons as part of routine contact tracing).
‡All serologic specimens were collected on June 5, 2014.

Main Article

Page created: July 15, 2016
Page updated: July 15, 2016
Page reviewed: July 15, 2016
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
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