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Volume 22, Number 9—September 2016
Letter

Bifidobacterium longum Subspecies infantis Bacteremia in 3 Extremely Preterm Infants Receiving Probiotics

Eirin EsaiassenComments to Author , Pauline Cavanagh, Erik Hjerde, Gunnar S. Simonsen, Ragnhild Støen, and Claus Klingenberg
Author affiliations: University Hospital of North Norway, Tromsø, Norway (E. Esaiassen, P. Cavanagh, G.S. Simonsen, C. Klingenberg); Arctic University of Norway, Tromsø (E. Esaiassen, E. Hjerde, G.S. Simonsen, C. Klingenberg); St. Olavs Hospital, Trondheim, Norway (R. Støen); Norwegian University of Science and Technology, Trondheim (R. Støen)

Main Article

Table

Characteristics of 3 extremely preterm infants with Bifidobacterium longum subspecies infantis bacteremia, 2015*

Characteristic Patient 1 Patient 2 Patient 3
NICU A B A
Sex M M F
Date of onset Apr Jul Sep
Gestational age, wk 24 23 24
Birth weight, g 730 500 697
Mode of delivery Vaginal Vaginal Caesarean section
Apgar score at 1, 5, and 10 min after birth 4, 5, 5 Unknown, 0, 4 2, 2, 3
Reason for prematurity Preterm rupture of membranes, maternal infection Sudden preterm rupture of membranes, delivery not attended by healthcare personnel Placental abruption
Age at onset of sepsis, d 8 12 46
Maximum CRP level, mg/L, <48 h of symptom onset 147 25 242
Age at discharge, wk 40 41 43
Weight at discharge, kg 3.3 3.4 3.3
Bacterial culture medium and conditions BacT/ALERT,† aerobic, 36°C BACTEC Plus,† aerobic, 35°C BacT/ALERT,† aerobic, 36°C
Bacterial growth in blood culture, d 2 3 2

*Patients were given ½ to 1 capsule/day of oral probiotics (Infloran; Laboratorio Farmacéutico Specialità Igienico Terapeutiche, Mede, Italy) that contained 109 Lactobacillus acidophilus (ATCC 4356) and 109 B. longum subspecies infantis (ATCC 15697). MICs (mg/L) for antimicrobial drugs tested were 0.016 for meropenem, 0.032 for ampicillin, 0.064 for penicillin, 0.064 for piperacillin/tazobactam, 0.250 for cefotaxime, 0.250 for clindamycin, 0.250 for vancomycin, and 4.000 for ciprofloxacin. All bacterial strains were inherently resistant to aminoglycosides. ATCC, American Type Culture Collection (Manassas, VA, USA); CRP, C-reactive protein; NICU, neonatal intensive care unit.
†bioMérieux (Marcy l’Étoile, France).

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Page created: August 16, 2016
Page updated: August 16, 2016
Page reviewed: August 16, 2016
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
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