Chromosomal Locations of mcr-1 and blaCTX-M-15 in Fluoroquinolone-Resistant Escherichia coli ST410
Linda Falgenhauer, Said-Elias Waezsada, Konrad Gwozdzinski, Hiren Ghosh, Swapnil Doijad, Boyke Bunk, Cathrin Spröer, Can Imirzalioglu, Harald Seifert, Alexandra Irrgang, Jennie Fischer, Beatriz Guerra
1, Annemarie Käsbohrer, Jörg Overmann, Alexander Goesmann, and Trinad Chakraborty
Author affiliations: Justus Liebig University, Giessen, Germany (L. Falgenhauer, S.-E. Waezsada, K. Gwozdzinski, H. Ghosh, S. Doijad, C. Imirzalioglu, A. Goesmann, T. Chakraborty); German Center for Infection Research, Giessen, Germany (L. Falgenhauer, S.-E. Waezsada, K. Gwozdzinski, H. Ghosh, S. Doijad, C. Imirzalioglu, T. Chakraborty); Leibniz Institute DSMZ—German Collection of Microorganisms and Cell Cultures, Braunschweig, Germany (B. Bunk, C. Spröer, J. Overmann); German Center for Infection Research, Braunschweig (B. Bunk, C. Spröer, J. Overmann); University of Cologne, Cologne, Germany (H. Seifert); German Center for Infection Research, Cologne (H. Seifert); Federal Institute for Risk Assessment, Berlin, Germany (A. Irrgang, J. Fischer, B. Guerra, A. Käsbohrer)
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Figure
Figure. A) Genetic environment of mcr-1 in extended-spectrum β–lactamase (ESBL)–producing food isolates including the original environment found in pHNSHP45. Colors represent gene functions and insertion sequences: purple, transposase of ISApl1; dark blue, ISApl1 element; green, mcr-1; pink, hypothetical protein within the mcr-1 transposition unit; red, light blue, yellow, flanking genes specific for the respective isolate. B) Phylogenetic tree (unrooted) of the Escherichia coli sequence type 410 isolates harboring the blaCTX-M-15 transposition unit in the chromosome and a schematic depiction of the location of the mcr-1 and blaCTX-M-15 transposition unit. Isolates prefixed with the letter E represent consecutive isolates from 1 patient. Scale bar indicates nucleotide substitutions per site.
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