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Volume 23, Number 2—February 2017
Research

Livestock Susceptibility to Infection with Middle East Respiratory Syndrome Coronavirus

Júlia Vergara-Alert1, Judith M.A. van den Brand1, W. Widagdo1, Marta Muñoz, Stalin Raj, Debby Schipper, David Solanes, Ivan Cordón, Albert Bensaid, Bart L. Haagmans, and Joaquim SegalésComments to Author 
Author affiliations: Centre de Recerca en Sanitat Animal, Barcelona, Spain (J. Vergara-Alert, M. Muñoz, D. Solanes, I. Cordón, A. Bensaid, J. Segalés); Erasmus Medical Center, Rotterdam, the Netherlands (J.M.A. van den Brand, W. Widagdo, V.S. Raj, D. Schipper, B.L. Haagmans); Universitat Autònoma de Barcelona, Barcelona (J. Segalés)

Main Article

Figure 3

Histology and expression of viral antigen (IHC) and viral RNA (ISH) at postinoculation day 4 in the nasal respiratory epithelium of sheep, pigs, llamas, and horses inoculated with MERS-CoV. A mild to severe rhinitis with epithelial necrosis and hypertrophy and inflammation of the epithelium and lamina propria was observed in the nasal respiratory tissue of pigs and llamas. Associated with these was presence of virus antigen (IHC) and RNA (ISH). No substantial lesions, virus antigen, or virus RNA

Figure 3. Histology and expression of viral antigen (IHC) and viral RNA (ISH) at postinoculation day 4 in the nasal respiratory epithelium of sheep, pigs, llamas, and horses inoculated with MERS-CoV. A mild to severe rhinitis with epithelial necrosis and hypertrophy and inflammation of the epithelium and lamina propria was observed in the nasal respiratory tissue of pigs and llamas. Associated with these was presence of virus antigen (IHC) and RNA (ISH). No substantial lesions, virus antigen, or virus RNA were detected in the nasal respiratory tissues of sheep and horses (HE, IHC, ISH). Original magnification ×200 for all images. HE, hematoxylin and eosin; IHC, immunohistochemistry; ISH, in situ hybridization; MERS-CoV, Middle East respiratory syndrome coronavirus.

Main Article

1These authors contributed equally to this article.

Page created: January 17, 2017
Page updated: January 17, 2017
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The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
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