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Volume 26, Number 7—July 2020
Research Letter

Rhabdomyolysis as Potential Late Complication Associated with COVID-19

Min Jin and Qiaoxia TongComments to Author 
Author affiliations: Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China (M. Jin); Department of Infectious Diseases, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan (Q. Tong)

Main Article

Table

Biochemistry and blood gas parameters of a 60-year-old man with severe acute respiratory syndrome coronavirus 2 infection and rhabdomyolysis, by day of hospitalization, Wuhan, China, 2020*

Parameter (reference range) Day 1 Day 3 Day 6 Day 9† Day 10 Day 11 Day 12‡ Day 15 Day 17 Day 20
Myoglobin (0–140 μg/L) ND ND ND >12,000 12,550 7,905 3,280 928 152 86
Creatine kinase (38–174 U/L) 47 ND ND 11,842 17,434 14,318 11,067 2,954 1,447 251
LDH (109–245 U/L) 280 ND ND 2,347 2,137 1,979 1,754 1,265 923 597
α-hbdh (72–182 U/L) 277 ND ND 1,612 1,436 1,171 1,143 1,037 911 189
Amyloid A (0–10 mg/L) 746 ND ND 429 192 105 126 93 84 25
CRP (0–8 mg/L) 111 123 206 58 45 23.4 23.4 21.4 6.1 15
ALT (5–40 U/L) 37 82 61 111 162 171 172 142 133 56
AST (8–40 U/L) 48 88 35 213 373 348 320 183 135 38
Albumin (35–55 g/L) 33.7 31.8 27.6 32.3 28.5 30.3 30 30.7 29.3 30.3
Creatine (44–133 μmol/L) 72.5 74.4 72.6 65.2 68.9 68.8 59.2 68 65.7 67.3
PH (7.35–7.45) ND ND ND ND 7.51 7.4 7.48 7.45 ND 7.40
PCO2 (35–45 mm Hg) ND ND ND ND 29.2 34.8 34.6 36 ND 38
PO2 (83–103 mm Hg) ND ND ND ND 49 147 142 120 ND 102

*α-hbdh, α-hydroxybutyrate dehydrogenase; ALT, alanine aminotransferase; AST, aspartate aminotransferase; LDH, lactate dehydrogenase; ND, not done.
†Rhabdomyolysis symptoms appeared on hospital day 9.
‡Real-time reverse transcription PCR conducted on hospital day 12 was negative for severe acute respiratory syndrome coronavirus 2.

Main Article

Page created: March 20, 2020
Page updated: June 18, 2020
Page reviewed: June 18, 2020
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
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